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Ensaios Clínicos – Contextualização abreviada e alguns desafios

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Linkage of cytosolic peroxiredoxin 2 to erythrocyte membrane imposed by hydroge...

Human erythrocyte peroxiredoxin 2 (Prx2) is a typical 2-cys cytosolic peroxiredoxin with thiol-dependent hydrogen peroxide scavenger activity. In a previous work, we reported Prx2 erythrocyte membrane linkage in some Hereditary Spherocytosis patients and that it seemed to be related to oxidative stress. The aim of the present work was to determine if Prx2 linkage to erythrocyte membrane could be induced by oxid...

Hepcidin serum levels and resistance to recombinant human erythropoietin therap...

This title was also presented orally at Clinical Biochemistry workshop,Faro, 29 Janeiro, 2010

Resistance to recombinant human erythropoietin therapy in haemodialysis patient...

Anaemia is a common complication in haemodialysis patients. This condition is associated to a decreased bone marrow production of erythrocytes, mainly due to the inability of the failing kidneys to secrete erythropoietin (EPO). The introduction of recombinant human EPO (rhEPO) therapy led to a significant reduction in anaemia and improved patients’ quality of life. However, there is a marked variability in the ...

Resistance to recombinant human erythropoietin therapy in haemodialysis patients

To better clarify the mechanism of resistance to recombinan thuman erythropoietin (rhEPO) therapy in haemodialysis patients, we studied systemic changes associated with resistance to rhEPO therapy in haemodialysis patients under rhEPO therapies, with particular interest on inflammation, leukocyte activation, iron status, oxidative stress and erythrocyte damage. We studied 63 chronic kidney disease (CKD) patient...

Inflammation, T-Cell phenotype, and inflammatory cytokines in chronic kidney di...

Background Resistance to recombinant human erythropoietin (rhEPO) occurs in some chronic kidney disease (CKD) patients, which may be due to enhanced systemic inflammatory response and to the erythropoiesis-suppressing effect of pro-inflammatory cytokines, some of which are produced by T cells. Aim of study The aim of this study was to investigate the relationship between resistance to rhEPO therapy in hemodialy...

Higher fibrinolytic and inflammatory markers are associated with central venous...

T-cell phenotype and inflammation in chronic kidney disease patients under haem...

IL-7 serum levels and lymphopenia in hemodialysis patients, non-responders to r...

DMT1 (NRAMP2/DCT1) genetic variability and resistance to recombinant human eryt...