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Dual Role of Topoisomerase II in Centromere Resolution and Aurora B Activity
Coelho, Paula A.; Queiroz-Machado, Joana; Carmo, Alexandre M.; Moutinho-Pereira, Sara; Maiato, Helder; Sunkel, Claudio E.Chromosome segregation requires sister chromatid resolution. Condensins are essential for this process since they organize an axial structure where topoisomerase II can work. How sister chromatid separation is coordinated with chromosome condensation and decatenation activity remains unknown. We combined four-dimensional (4D) microscopy, RNA interference (RNAi), and biochemical analyses to show that topoisomera...
Data: 2008
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Origem: Repositório Aberto da Universidade do Porto
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