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Solubility of drug-like molecules in pure, mixed and supercritical solvent syst...

Most of the active pharmaceutical ingredients (API) are purified by crystallization being solubility a key property, and it also affects their efficacy, release, transport and absorption in the organism [1]. Although of extreme importance, data involving druglike molecules are still scarce. In recent years, efforts have been made towards the development of predictive tools to calculate phase behaviour of the AP...