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Avaliação do Estado Redox Plasmático na Criança
Diogo, L.; Drago, H.; Fernandes, A.; Carvalho, G.; Canha, J.; Mota, H. C.; Proença, T.; Oliveira, C.A avaliação do estado redox plasmático, que consiste na determinação simultânea das concentrações plasmáticas de lactato, piruvato, acetoacetato e P-hidroxibutirato, é útil no rastreio das doenças hereditárias do metabolismo por défice energético. O seu doseamento exige rigorosas condições de colheita e processamento das amostras. Fez-se o estudo de 70 crianças sem doença metabólica com idades compreendidas ent...
Oxidative Stress Adaptation in Aggressive Prostate Cancer May Be Counteracted b...
Freitas, M; Baldeiras, I; Proença, T; Alves, V; Mota-Pinto, A; Sarmento-Ribeiro, AOxidative stress has been associated with prostate cancer development and progression due to an increase of reactive oxygen species (ROS). However, the mechanisms whereby ROS and the antioxidant system participate in cancer progression remain unclear. In order to clarify the influence of oxidative stress in prostate cancer progression, we performed this study in two human prostate cancer cell lines, PC3 and HP...
Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-...
Sena, C. M.; Nunes, E.; Louro, T.; Proença, T.; Fernandes, R.; Boarder, M. R.; Seiça, R. M.Background and purpose: This study was conducted to investigate the effects of α-lipoic acid (α-LA) on endothelial function in diabetic and high-fat fed animal models and elucidate the potential mechanism underlying the benefits of α-LA. Experimental approach: Plasma metabolites reflecting glucose and lipid metabolism, endothelial function, urinary albumin excretion (UAE), plasma and aortic malondialdehyde (MDA...
Disfunção Endotelial na Diabetes Tipo 2: Efeito de Antioxidantes
Sena, CM; Nunes, E; Louro, T; Proença, T; Seiça, RMIndividuals with insulin resistance and diabetes mellitus have increased cardiovascular morbidity and mortality, caused in part by vascular complications. Endothelial dysfunction has been implicated in the pathogenesis of vascular diabetic disease. This abnormal function of the vasculature precedes cardiovascular disease and is associated with impaired endothelium-dependent vasorelaxation. The main etiology of ...
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