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Blood flow in a bifurcation and confluence microchannel : the effectof the cell...
Pinho, Diana; Bento, David; Rodrigues, Raquel; Fernandes, Carla S.; Garcia, Valdemar; Lima, R.A few detailed studies have been performed in complex in vitro microvascular networks composed by bifurcations and confluences. The main purpose of the present work is to numerically simulate the flow of two distinct fluids through bifurcation and confluence geometries, i. e red blood cells (RBCs) suspended in Dextran40 with about 14% of heamatocrit and pure water. The simulations of pure water and RBCs flows w...
Blood flow in a bifurcation and confluence microchannel : effect of the cell-...
Pinho, Diana; Bento, David; Rodrigues, Raquel; Fernandes, Carla S.; Garcia, Valdemar; Lima, R.A few detailed studies have been performed in complex in vitro microvascular networks composed by bifurcations and confluences. The main purpose of the present work is to numerically simulate the flow of two distinct fluids through bifurcation and confluence geometries, i. e red blood cells (RBCs)suspended in Dextran40 with about 14% of heamatocrit and pure water. The simulations of pure water and RBCs flows we...
Visualization and measurement of red blood cells flowing in microfluidic devices
Rodrigues, Raquel; Pinho, Diana; Faustino, Vera; Yaginuma, T.; Bento, David; Fernandes, Carla S.; Garcia, Valdemar; Lima, R.Several experimental techniques were performed in the past years using in vitro environments, in an attempt to not only understand the blood flow behaviour in microcirculation but also develop microfluidic devices as an alternative clinical methodology to detect blood diseases. Hence, the visualization and measurement of red blood cells (RBCs) flowing in a microfluidic device are important to provide not only e...
Cell-free layer (CFL) measurements in complex geometries: contractions and bifu...
Novais, Susana; Pinho, Diana; Bento, David; Pinto, Elmano; Yaginuma, Tomoko; Fernandes, Carla S.; Garcia, Valdemar; Pereira, Ana I.; Lima, JoséIn this chapter we discuss the cell-free layer (CFL) developed adjacent to the wall of microgeometries containing complex features representative of the microcirculation, such as contractions, expansions, bifurcations and confluences. The microchannels with the different geometries were made of polydimethylsiloxane (PDMS) and we use optical techniques to evaluate the cell-free layer for red blood cells (RBC) su...
Cell-free layer measurements in a bifurcation microchannel : comparison between...
Bento, David; Pinho, Diana; Pinto, Elmano; Yaginuma, Tomoko; Correia, Teresa Montenegro; Lima, José; Pereira, Ana I.; Lima, R.In the present work, in vitro blood flowing through a bifurcation microchannel was studied. The aim was to measure the Trajectories of the cell-free layer (CFL) by using different methods, i. e., a manual and two automatic methods.
Cell-free layer measurements in a bifurcation microchannel : comparison between...
Bento, David; Pinho, Diana; Pinto, Elmano; Yaginuma, Tomoko; Correia, Teresa Montenegro; Lima, José; Pereira, Ana I.; Fernandes, Carla S.O artigo deve também estar associado ao Departamento de Electrotécnia, Tecnologia Mecânica e Química ; In the present work, in vitro blood flowing through a bifurcation microchannel was studied. The aim was to measure the Trajectories of the cell-free layer (CFL) by using different methods, i. e., a manual and two automatic methods.
Fabricação de microcanais utilizando o método de xurografia: visualização da ca...
Pinto, Elmano; Pinho, Diana; Bento, David; Correia, Teresa Montenegro; Garcia, Valdemar; Dias, Ricardo P.; Miranda, João Mário; Lima, R.No presente estudo, pretendeu-se desenvolver/melhorar uma metodologia de microfabricação de baixo custo, conhecida por xurografia e efectuar a visualização e quantificação da camada livre de células (CLC) junto às paredes para diferentes escoamentos sanguíneos em microcanais.
Flow of red blood cells in microchannel networks : in vitro studies
Cidre, Diana; Rodrigues, Raquel Oliveira; Faustino, V.; Pinto, Elmano; Pinho, Diana; Bento, David; Fernandes, Carla S.; Dias, Ricardo P.; Lima, R.Human blood is a multiphase biofluid primarily composed by the deformable red blood cells (RBCs) suspended in plasma. Because the complex structure of RBCs, blood exhibits unique flow characteristics on micro-scale level, due to their complex biochemical mechanisms and their response to both shear and extensional flow, which influence the rheological properties and flow behaviour of blood [1,2]. In the past yea...
Separation and deformation of red blood cells in PDMS microchannels
Rodrigues, Raquel Oliveira; Faustino, V.; Pinho, Diana; Pinto, Elmano; Cidre, Diana; Yaginuma, Tomoko; Taboada, B.; Bento, David; Lima, R.Over the years, several experimental techniques were performed in in vitro environments, in an attempt to understand the flow behaviour of blood in microcirculation. Several of these studies were performed in glass capillaries, and have produced significant results with respect to rheological properties of blood [1, 2]. Another way to perform in vitro blood studies is to use microchannels fabricated by soft- li...
Método automático para a medição da espessura camada de plasma em microcanais...
Bento, David; Cidre, Diana; Lima, José; Dias, Ricardo P.; Lima, R.Ao longo dos anos, a espessura da camada de plasma tem sido determinada com o auxilio de métodos manuais. Apesar destes métodos serem bastante fiáveis, estes são morosos e podem introduzir erros do utilizador nos dados. No presente trabalho, foi desenvolvido um método automático de processamento de imagem para a determinação da espessura camada de plasma de uma forma automática.
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