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Early cyclosporine a withdrawal in kidney-transplant recipients receiving sirol...
Ruiz, JC; Campistol, JM; Grinyó, JM; Mota, A; Prats, D; Gutiérrez, JA; Henriques, ACBACKGROUND: Nephrotoxicity of calcineurin inhibitors (CNIs) is partially responsible for the development of chronic allograft nephropathy (CAN). Sirolimus has demonstrated its potential to substitute for CNIs because it lacks significant nephrotoxicity and shows a short-term immunosuppressive capacity comparable with that of cyclosporine. This results in the maintenance of better renal function when cyclosporin...
Early elimination of cyclosporine in kidney transplant recipients receiving sir...
Ruiz, JC; Campistol, JM; Mota, A; Prats, D; Gutiérrez, JA; Castro, A; Morales, JCyclosporine elimination in a regimen including sirolimus has been shown to be a safe and effective approach to improve graft function. Nevertheless, it is still unknown whether the functional benefit of CyA withdrawal coincides with a subsequent reduction in histologic lesions of chronic damage or development of chronic allograft nephropathy. This consideration would forecast a reduction in the rate of long-te...
Early cyclosporine a withdrawal in kidney transplant recipients under a sirolim...
Ruiz, JC; Campistol, JM; Mota, A; Prats, D; Gutiérrez, A; Castro, A; Pinto, JR
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