Encontrados 4 documentos, a visualizar página 1 de 1
High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations
Teixeira,D.; Vargens,D.; Príncipe,A.; Oliveira,E.; Amorim,A.; Prata,M.J.; Suarez-Kurtz,G.A 3-bp insertion/deletion polymorphism in intron 6 of GSTM3 (rs1799735, GSTM3*A/*B) affects the activity of the phase 2 xenobiotic metabolizing enzyme GSTM3 and has been associated with increased cancer risk. The GSTM3*B allele is rare or absent in Southeast Asians, occurs in 5-20% of Europeans but was detected in 80% of Bantu from South Africa. The wide genetic diversity among Africans led us to investigate wh...
Analysis of Y-chromosome Variability and its Comparison with mtDNA Variability ...
Montiel, R.; Bettencourt, C.; Silva, C.; Santos, C.; Prata, M. J.; Lima, M.We determined the Y-chromosomal composition of the population of the Azores Islands (Portugal), by analyzing 20 binary polymorphisms located in the non-recombining portion of the Y-chromosome (NRY), in 185 unrelated individuals from the three groups of islands forming the Archipelago (Eastern, Central and Western). Similar to that described for other Portuguese samples, the most frequent haplogroups were R1(xR1...
Pattern of mtDNA Variation in Three Populations from São Tomé e Príncipe
Trovoada, M. J.; Pereira, L.; Gusmão, L.; Abade, A.; Amorim, A.; Prata, M. J.We have analysed the matrilineal genetic composition of three self-reported ethnic groups from São Tomé e Príncipe (Gulf of Guinea), an African archipelago whose settlement begun in the late fifteenth century. Sequence data from the hypervariable segments I (HVS-I) and II (HVS-II) were obtained for 30 Angolares, 35 Forros and 38 Tongas. The repertory of mtDNA lineages in São Tomé e Príncipe denoted a fully Afri...
Evidence for population sub-structuring in São Tomé e Príncipe as inferred from...
Trovoada, M. J.; Alves, C.; Gusmão, L.; Abade, A.; Amorim, A.; Prata, M. J.Seven Y-chromosome STR loci, DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392 and DYS393 have been analysed in population samples of Angolares, Forros and Tongas, three ethnic groups from the African archipelago of São Tomé e Príncipe (Gulf of Guinea). Complete typings were obtained for 103 chromosomes, which belonged to 79 different haplotypes. The mean heterozygosity per locus in the overall São Tomean sample...
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