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Sirolimus-Induced Drug Fever in a Renal Transplant Patient: a Case Report
Aires, I; Carvalho, D; Remédio, F; Possante, M; Ferreira, A; Pinto, JR; Nolasco, F; Ribeiro Santos, JHerein we have described the case of a male renal transplant recipient who developed drug fever apparently related to sirolimus. He had been stable under an immunosuppressive regimen of tacrolimus and mycophenolate mofetil, but developed acute cellular rejection at 5 years after transplantation due to noncompliance. Renal biopsy showed marked interstitial fibrosis, and immunosuppression was switched from mycoph...
Leflunomide and Polyomavirus-Associated Nephropathy in Renal Transplant
Ferreira, AC; Ferreira, A; Possante, M; Sousa, J; Viana, H; Carvalho, H; Nolasco, FPolyomavirus nephropathy is a major complication in renal transplantation, associated with renal allograft loss in 14 to 80% of cases. There is no established treatment, although improvement has been reported with a variety of approaches. The authors report two cases of polyomavirus infection in renal allograft recipients. In the first case, a stable patient presented with deterioration of renal function, worse...
Leukopenia in Kidney Transplant Patients with the Association of Valganciclovir...
Brum, S; Nolasco, F; Sousa, J; Ferreira, A; Possante, M; Pinto, JR; Barroso, E; Ribeiro Santos, JCytomegalovirus (CMV) is the most common viral infection after transplantation. Valganciclovir (VGC) is established for prophylaxis and treatment of CMV infections, but leukopenia which appears in 10% to 13% (severe in 4.9%) is the principal side effect. We have recently noted an increased incidence of leukopenia and severe neutropenia among our renal transplant patients and thought to identify the associated f...
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