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Polymorphism in gidB gene as a genetic marker for the mycobacterium tuberculosi...
Perdigão, João; Macedo, Rita; Machado, Diana; Silva, Carla; Jordão, Luisa; Couto, Isabel; Viveiros, Miguel; Portugal, IsabelDevelopment of streptomycin-resistance in Mycobacterium tuberculosis is usually associated with mutations in rpsL and rrs genes, although up to 50% of clinical streptomycin-resistant isolates may present no mutation in either of these genes. The situation in Lisbon Health Region is similar, although mutations in rrs gene are only rarely detected. In the present report we investigate the role of gidB gene mutati...
Novel Mutations in pncA, Associated With Catalytic Centre, Might Be Related Wit...
Silva, Carla; Perdigao, João; Jordao, Luísa; Portugal, IsabelTuberculosis (TB) remains a serious health problem worldwide, and the greatest threat to TB control is the emergence of multidrug (MDR) Mycobacterium tuberculosis (Mtb) strains. Pyrazinamide (PZA) is an important first-line anti-TB drug. The emergence of isolates resistant to PZA, associated with MDR resistance, difficult TB treatment options. In order to evaluate mutations that might be responsible for PZA res...
Genomic diversity of drug-resistant mycobacterium tuberculosis isolates in Lisb...
Perdigão, João; Silva, Hugo; Machado, Diana; Macedo, Rita; Maltez, Fernando; Silva, Carla; Jordão, Luisa; Couto, Isabel; Mallard, Kim; Coll, FrancescMultidrug- (MDR) and extensively drug resistant (XDR) tuberculosis (TB) present a challenge to disease control and elimination goals. Lisbon, Portugal, has a high TB incidence rate and, unusual and successful XDR-TB strains that are found in circulation for almost two decades. In the present study, 56 Mycobacterium tuberculosis isolates, mostly recovered in Lisbon, were genotyped by 24-loci Mycobacterial Inters...
Correlation between streptomycin intermediate-level resistance and gidB mutatio...
Perdigao, joão; Macedo, Rita; Machado, Diana; Silva, Carla; Jordao, Luisa; Couto, Isabel; Viveiros, Miguel; Portugal, IsabelDevelopment of streptomycin-resistance in Mycobacterium tuberculosis is usually associated with mutations in rpsL and rrs genes, although up to 50% of clinical streptomycin-resistant isolates may present no mutation in either of these genes. The situation in Lisbon Health Region is similar, although mutations in rrs geneare only rarely detected. In the present report we investigate the role of gidB gene mutatio...
Exploring a link between mycobacteria structure and virulence
Silva, Carla; Perdigao, Joao; Alverca, Elsa; Matos, António Pedro Alves; Carvalho, Patrícia A; Portugal, Isabel; Jordao, LuisaTuberculosis (TB) is a major health problem. The emergence of multidrug resistant (MDR)Mycobacterium tuberculosis (Mtb) isolates confounds treatment strategies. In Portugal, cases of MDR-TB are reported annually with increased incidence noted in Lisbon. The majority of these MDR-TB cases are due to closely-related mycobacteria known collectively as Lisboa family and Q1 cluster. The genetic determinants linked t...
Morphologic characterization of Mycobacterium tuberculosis circulating strains ...
Silva, Carla; Alverca, Elsa; Matos, António Pedro; Carvalho, Patricia A; Portugal, Isabel; Jordao, LuisaAbstrat publicado em: http://metallica.civil.ist.utl.pt/~patricia/SPMicros2012/book.pdf ; Tuberculosis (TB) is one of the major causes of mortality and morbidity worldwide accounting for 3.1 million deaths per year. This disease, caused by M. tuberculosis (Mtb) made a deadly, during the 1990’s, triggered mainly by the emergence of acquired immunodeficiency syndrome (AIDS). More recently, the emergence of multi...
Molecular analysis on resistant TB isolates in Portugal
Silva, Carla; Perdigao, Joao; Jordao, Luisa; Portugal, IsabelAbstrat publicado em: http://www.pasteur.fr/infosci/conf/sb/tuberculosis2012/images/TB2012-Program-Abstract-book-LD.pdf ; Portugal has one of the highest tuberculosis (TB) incidence (20/100 000 inhabitants) in Europe. The emergence of multidrug resistant (MDR) TB and extensive drug-resistant (XDR) TB infection is the biggest threat to TB control. Most strains of MDR-TB circulating in the Lisbon area belong to ...
Dynamics and Development of Extensively Drug-resistant Tuberculosis, Portugal
Perdigao, Joao; Silva, D.; Pereira, V.; Macedo, Rita; Silva, Carla; Machado, Diana; Couto, Isabel; Viveiros, Miguel; Jordao, Luisa; Portugal, IsabelAbstrat publicado em: http://www.pasteur.fr/infosci/conf/sb/tuberculosis2012/images/TB2012-Program-Abstract-book-LD.pdf ; The development of multidrug-resistant (MDR) and extensive drug-resistant (XDR) tuberculosis(TB) combined with subsequent transmission constitutes a serious threat to the effective control of tuberculosis in several countries. Lisbon Health Region, despite great progresses in TB management ...
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