Encontrados 5 documentos, a visualizar página 1 de 1
HIV-2 Integrase Polymorphisms and Longitudinal Genotypic Analysis of HIV-2 Infe...
Cavaco-Silva, J; Abecasis, A; Miranda, AC; Poças, J; Narciso, J; Águas, MJ; Maltez, F; Almeida, I; Germano, I; Diniz, A; Gonçalves, MF; Gomes, PTo characterize the HIV-2 integrase gene polymorphisms and the pathways to resistance of HIV-2 patients failing a raltegravir-containing regimen, we studied 63 integrase strand transfer inhibitors (INSTI)-naïve patients, and 10 heavily pretreated patients exhibiting virological failure while receiving a salvage raltegravir-containing regimen. All patients were infected by HIV-2 group A. 61.4% of the integrase r...
Infecção por vírus West Nile [Flavivírus] em Portugal. Considerações acerca de ...
Alves, M.J.; Poças, J.M.; Luz, T.; Amaro, F.; Zé-Zé, L.; Osório, H.O vírus West Nile [WN] é um flavivírus transmitido por mosquitos e agente etiológico de febre e de doença neuroinvasiva. O vírus WN mantém-se na natureza em ciclos enzoóticos que envolvem mosquitos ornitofílicos, como vectores primários, e algumas espécies de aves como reservatório primário. A sua presença em Portugal é conhecida, surgindo esporadicamente alguns casos de infecção em equinos e humanos. Em 2010 f...
Host- and microbe-related risk factors for and pathophysiology of fatal Rickett...
Sousa, R; França, A; Nóbrega, SD; Belo, A; Amaro, M; Abreu, T; Poças, J; Proença, P; Vaz, J; Torgal, J; Bacellar, F; Ismail, N; Walker, DBACKGROUND: The pathophysiologic mechanisms that determine the severity of Mediterranean spotted fever (MSF) and the host-related and microbe-related risk factors for a fatal outcome are incompletely understood. METHODS: This prospective study used univariate and multivariate analyses to determine the risk factors for a fatal outcome for 140 patients with Rickettsia conorii infection admitted to 13 Portuguese h...
Intralesional expression of mRNA of interferon- gamma, tumor necrosis factor- a...
Sousa, R; Ismail, N; Nóbrega, SD; França, A; Amaro, M; Anes, M; Poças, J; Coelho, R; Torgal, J; Bacellar, F; Walker, DBACKGROUND: The mechanisms of immunity to Rickettsia conorii that have been elucidated in mouse models have not been evaluated in human tissues. METHODS: In this study, quantitative real-time polymerase chain reaction was used to determine the levels of expression of inflammatory and immune mediators in skin-biopsy samples collected from 23 untreated patients with Mediterranean spotted fever (MSF). RESULTS: In ...
Vasculitis associated with ANCA.
Parreira, M; Serviço de Medicina II, Hospital Distrital de Setúbal.; Custódio, P; Sá, J; Mendes, J; Mendes, A P; Poças, JThe authors present a case report of a 62-year old woman, with hypertension for many years. She suffered from weakness, anorexia and weight loss in the last 6 months. On admission, anemia, elevated ESR, haematuria, proteinuria and renal failure were present. Renal biopsy was compatible with chronic glomerulonephritis. The clinical picture and positivity for P-ANCA suggested systemic vasculitis. Later evidence o...
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