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Association and Expression Study of PRKCH Gene in a French Caucasian Populatio...

Teixeira, Vitor; Jacq, Laurent; Moore, Jeoiakim; Lasbleiz, Sandra; Hilliquin, Pascal; Oliveira, Catarina Resende; Cornelis, François

We study the association between three protein kinase C, eta gene polymorphisms (+8134C/T, rs912620, rs959728), and susceptibility to rheumatoid arthritis. One hundred French Caucasian rheumatoid arthritis trio families were genotyped. Relative quantification of protein kinase C, eta mRNA expression was performed from whole blood in 24 unrelated rheumatoid arthritis patients and in 16 healthy controls. Our resu...


HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French...

Jacq, Laurent; Teixeira, Vitor; Garnier, Sophie; Michou, Laëtitia; Dieudé, Philippe; Rocha, Dominique; Pierlot, Céline; Lemaire, Isabelle

Abstract The heat shock 60-kDa protein 1 (HSP60) is involved in immune and inflammatory reactions, which are hallmarks of rheumatoid arthritis (RA). HSP60 is encoded by the HSPD1 gene located on 2q33, one of the suggested RA susceptibility loci in the French Caucasian population. Our aim was to test whether HSPD1 is a major susceptibility gene by studing families from the French Caucasian population. Three sin...


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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia