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N-acetylcysteine and vancomycin alone and in combination against staphylococci ...
Leite, Bruna; Gomes, Fernando; Melo, P.; Souza, Clovis; Teixeira, P.; Oliveira, Rosário; Pizzolitto, ElisabethIntroduction: The ability of staphylococci to produce biofilm is an important virulence mechanism that allows bacteria both to adhere and to live on artificial surfaces and to resist to the host immune factors and antibiotics. Staphylococcal infections have become increasingly difficult to treat due their antibiotic resistance. Therefore, there is a continuous need for new and effective treatment alternatives a...
Staphylococcus epidermidis biofilms control by N-acetylcysteine and rifampicin
Leite, Bruna; Gomes, F. I.; Teixeira, P.; Souza, Clovis; Pizzolitto, Elisabeth; Oliveira, RosárioMedical device-associated infections caused by Staphylococcus epidermidis usually involve biofilm formation and its eradication is particularly challenging. Although rifampicin has been proving to be one of the most effective antibiotics against S. epidermidis biofilms, its use as a single agent can lead to the acquisition of resistance. Therefore, we assessed the combined effect of rifampicin with N-acetylcyst...
In vitro activity of daptomycin, linezolid and rifampicin on Staphylococcus epi...
Leite, Bruna; Gomes, F. I.; Teixeira, P.; Souza, Clovis; Oliveira, Rosário; Pizzolitto, ElisabethOwing to their massive use, Staphylococcus epidermidis has recently developed significant resistance to several antibiotics, and became one of the leading causes of hospital-acquired infections. Current antibiotics are typically ineffective in the eradication of bacteria in biofilmassociated persistent infections. Accordingly, the paucity of effective treatment against cells in this mode of growth is a key fact...
Response of Staphylococcus epidermidis biofilms cells to the effect of farnesol
Leite, Bruna; Gomes, F.I.; Teixeira, P.; Pizzolitto, Elisabeth; Oliveira, RosárioObjective:Staphylococcus epidermidis is a leading cause of medical-device-related infections, especially in immunocompromised patients. The treatment of these infections is further complicated by the emergence of multiresistant strains. The ability of S. epidermidis to form biofilms on biotic and abiotic surfaces is believed to contribute significantly to the pathogenesis of these infections. Biofilms are notor...
Effect of N-Acetylcysteine alone and in combination with rifampicin on Staphylo...
Leite, Bruna; Gomes, F. I.; Teixeira, P.; Souza, Clovis; Pizzolitto, Elisabeth; Oliveira, RosárioMedical device-associated infections caused by pathogens such as Staphylococcus epidermidis might involve biofilm formation and those are particularly challenging. The involvement of antibiotic resistant Staphylococci, exacerbates the problem. Rifampicin cannot be used as a single agent to treat infections because of the rapid selection of resistant mutants. However, combinations of rifampicin with other anti-s...
Streptococcus mutans attachment on a cast titanium surface
Rocha,Sicknan Soares da; Bernardi,Adilson César Abreu; Pizzolitto,Antônio Carlos; Adabo,Gelson Luis; Pizzolitto,Elisabeth LoshchaginThis study examined by means of scanning electron microscopy (SEM), the attachment of Streptococcus mutans and the corrosion of cast commercially pure titanium, used in dental dentures. The sample discs were cast in commercially pure titanium using the vacuum-pressure machine (Rematitan System). The surfaces of each metal were ground and polished with sandpaper (#300-4000) and alumina paste (0.3 µm). The roughn...
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