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Effect of monocytes/macrophages on the early osteogenic differentiation of hBMSCs
Pirraco, R. P.; Reis, R. L.; Marques, A. P.Heterotypic cell interactions are essential for the homeostasis of bone tissue, in particular the widely studied interaction between osteoblasts and osteoclasts. Closely related with osteoclasts are monocytes/macrophages. These have been shown to produce osteogenic factors, e.g. BMP-2, which plays a key role in bone metabolism. However, the mechanisms through which monocytes/macrophages interact with osteoblast...
Human adipose stem cells cell sheet constructs impact epidermal morphogenesis i...
Cerqueira, M. T.; Pirraco, R. P.; Santos, T. C.; Rodrigues, D. B.; Frias, A. M.; Martins, A.; Reis, R. L.; Marques, A. P.Among the wide range of strategies to target skin repair/regeneration, tissue engineering (TE) with stem cells at the forefront, remains as the most promising route. Cell sheet (CS) engineering is herein proposed, taking advantage of particular cell-cell and cell-extracellular matrix (ECM) interactions and subsequent cellular milieu, to create 3D TE constructs to promote full-thickness skin wound regeneration. ...
Improved regeneration of mice full-thickness excisional wounds by human adipose...
Cerqueira, M. T.; Santos, T. C.; Pirraco, R. P.; Frias, A. M.; Martins, A. R.; Reis, R. L.; Marques, A. P.A totalidade dos resumos foram publicados em "J. Tissue Eng. Regen. Med. 2012; 6 (Suppl. 2) : 8–39."
Perivascular-like cells contribute to the stability of the vascular network of ...
Mendes, L. F.; Pirraco, R. P.; Szymczyk, Wojciech; Frias, A. M.; Santos, T. C.; Reis, R. L.; Marques, A. P.In recent years several studies have been supporting the existence of a close relationship in terms of function and progeny between Mesenchymal Stem Cells (MSCs) and Pericytes. This concept has opened new perspectives for the application of MSCs in Tissue Engineering (TE), with special interest for the pre-vascularization of cell dense constructs. In this work, cell sheet technology was used to create a scaffol...
Pericytes contribute to the stability of the vascular network of osteogenic tis...
Mendes, L. F.; Pirraco, R. P.; Szymczyk, Wojciech; Santos, T. C.; Frias, A. M.; Reis, R. L.; Marques, A. P.Despite the increased use of cell sheets for tissue engineering, the appli- cation of this new technology for thick tissue reconstruction is being limited by old barriers such as the need to create a pre-vascular net- work to ensure proper nutrient and oxygen supply in vivo. In the pres- ent work, we created a cell sheet-based construct by co-culturing bone marrow-derived osteogenic and pericyte-like cells with...
Hyaluronic acid/poly(amidoamine) dendrimer nanoparticles for central nervous sy...
Silva, Barbara L.; Cerqueira, Susana R.; Fevereiro, J. P.; Pirraco, R. P.; Marques, A. P.; Oliveira, Joaquim M.; Reis, R. L.; Sousa, NunoCentral nervous system (CNS) disorders are among the diseases with less efficiency in treatment. In order to reach its target and exert its effect within the brain parenchyma, drugs must overcome the blood brain barrier (BBB) and the blood-cerebrospinal fluid-brain (BCSFB). The aim of this work was to develop a novel nano-based dendrimer which could serve as a nanocarrier with the ability to cross these barri- ...
Fibroblasts regulate osteoblasts through gap junctional communication
Pirraco, R. P.; Cerqueira, M. T.; Reis, R. L.; Marques, A. P.Fibroblasts are present in most tissues of the body, playing an active role in the regulation of homeostasis in such tissues. While fibroblast heterotypic interactions are acknowledged in the regeneration of tissues such as skin and periodontal ligament, their role in bone regeneration is far from being understood. We hypothesized that fibroblasts could influence osteoblasts, and as connexin 43 is the predomina...
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