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Synergistic impact of endurance training and intermittent hypobaric hypoxia on ...

Background Intermittent hypobaric-hypoxia (IHH) and endurance-training (ET) are cardioprotective strategies against stress-stimuli. Mitochondrial modulation appears to be an important step of the process. This study aimed to analyze whether a combination of these approaches provides additive or synergistic effects improving heart-mitochondrial and cardiac-function. Methods Two-sets of rats were divided into no...

Neuregulin-1 decreases the passive force of cardiomyocytes from the right ventr...

[Abstract] ; [Resumo]

Neuregulin-1 treatment reduces the severity of pulmonary arterial hypertension

[Abstract] ; [Resumo]

Rodent models of heart failure: an updated review

Heart failure (HF) is one of the major health and economic burdens worldwide, and its prevalence is continuously increasing. The study of HF requires reliable animal models to study the chronic changes and pharmacologic interventions in myocardial structure and function and to follow its progression toward HF. Indeed, during the past 40 years, basic and translational scientists have used small animal models to ...

Antiangiogénicos na Degenerescência Macular Relacionada com a Idade: a medicina...

Terapêutica Fotodinâmica no tratamento da Coriorretinopatia Serosa Central Crón...

Modulation of myocardial stiffness by beta-adrenergic stimulation - its role in...

The acute effects of beta-adrenergic stimulation on myocardial stiffness were evaluated. New-Zealand white rabbits were treated with saline (control group) or doxorubicin to induce heart failure (HF) (DOXO-HF group). Effects of isoprenaline (10(-10)-10(-5) M), a non-selective beta-adrenergic agonist, were tested in papillary muscles from both groups. In the control group, the effects of isoprenaline were also e...

Apelin decreases myocardial injury and improves right ventricular function in m...

We investigated the endogenous production of apelin and the cardiac and pulmonary effects of its chronic administration in monocrotaline (MCT)-induced pulmonary hypertension (PH). Male Wistar rats were injected with MCT (60 mg/kg sc) or vehicle (day 0). One week later, these animals were randomly treated during 17 days with pyroglutamylated apelin-13 (Pyr-AP13; 200 microg*kg(-1)*day(-1) ip) or a similar volume ...

O vírus da imunodeficiência humana no contexto da procriação medicamente assist...

No início da epidemia da SIDA, devido ao mau prognóstico das pessoas infectadas com a doença, os casais com um parceiro infectado com VIH eram desencorajados de planear uma gravidez. Actualmente, a SIDA mantém-se como uma condição grave a nível mundial, e mesmo nos países industrializados onde estão disponíveis tratamentos inovadores e eficazes, a infecção por VIH continua a ser uma doença crónica com elevada m...

Opisthorchis felineus in cat: case report

Opisthorchis felineus foi encontrado em um gato admitido no Hospital Veterinário da Universidade de Trás-os-Montes e Alto Douro. No momento de admissão, o animal apresentava-se em estado de choque, com hipotermia, desidratação e mucosas pálidas. As análises hematológicas revelaram linfopenia, eosinofilia e anemia moderada. À necrópsia observou-se distensão da vesícula biliar e intensa infestação parasitária no ...