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A Fitoterapia no tratamento da obesidade

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas ; A obesidade é um problema de saúde pública mundial, apresentando um significativo aumento na sua prevalência nas últimas décadas. Apesar de existirem diferentes definições de obesidade, de acordo com a Organização Mundial de Saúde (OMS), a obesida...

Epstein-Barr virus in healthy individuals from Portugal.

The Epstein-Barr virus (EBV) persists for long periods in latent state inside B-lymphocytes after primary infections, and reactivation usually occurs associated to immunosuppression conditions of the host. Recently, the detection of EBV DNA in circulation has been suggested as a predictor marker for the development of EBV related malignancies.The aim of our study was to characterize the frequency of circulating...

Is there a biological plausability for p53 codon 72 polymorphism influence on c...

The interaction between HPV E6 and p53 protein is known as the most important event in HPV-associated carcinogenesis. Some in vitro studies suggested that p53 genetic variants are targeted for ubiquitin-proteasome degradation induced by E6 with different abilities. A common p53 variant at position 72 (R72P) has leaded to the development of several studies regarding its role on cervical cancer development. Howev...

The predictive and monitoring value of serum HER2/NEU in breast cancer under tr...

In breast cancer, the Human Epidermal growth factor Receptor 2 (HER2) is associated with worst prognosis in all stages of the disease, and it is specifically targeted by a monoclonal antibody (trastuzumab). Nevertheless, the different response rates observed have increased the search for better predictive markers. Elevated levels of the extracellular domain of HER2/neu in the serum have been associated with the...

Anestesia espinhal com 10 mg de bupivacaína hiperbárica associada a 5 µg de suf...

JUSTIFICATIVA E OBJETIVOS: Diversos fatores influenciam na dispersão cefálica da solução anestésica no espaço subaracnóideo, entre os quais destacam-se as alterações fisiológicas inerentes à gravidez, baricidade, dose e volume do anestésico local. O objetivo deste estudo foi avaliar em cesarianas a efetividade e os efeitos colaterais de diferentes volumes da associação de bupivacaína hiperbárica e sufentanil po...

Teste de germinação de sementes de sansão-do-campo (mimosa caesalpiniaefolia be...

A pesquisa avaliou a temperatura e o substrato para o teste de germinação das sementes de sansão-do-campo (Mimosa caesalpiniaefolia Benth.). Inicialmente, foram avaliados, em mesa termogradiente, 11 intervalos de temperaturas entre 15°C e 35°C, sob oito horas de fotoperíodo diário. A seguir, utilizando as temperaturas mais adequadas (30°C e 35°C), em germinadores, com oito horas de fotoperíodo diário, foram tes...

Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ...

The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case–control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (ORZ2.46 95% CI 1.20–5.06; PZ...

Raquianestesia: quebra de agulha no espaço intervertebral

Acetylation genotype and the genetic susceptibility to postate cancer in a Sout...

Epidemiologic studies have suggested that environmental factors and diet are important risk factors in the pathogenesis of prostate cancer. The N-acetyltransferases (NAT) are important enzymes in activation and inactivation of various carcinogens, including those found in well-cooked meat and cigarette smoke. METHODS. We analyzed DNA samples from 146 prostate cancer patients and 174 healthy men. We used PCR–RFL...

Polimorfismo no gene HER2 no cancro da mama e do ovário

Dissertação de Mestrado em Oncologia apresentada ao Instituto de Ciências Biomédicas de Abel Salazar da Universidade do Porto