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In vitro degradation and in vivo biocompatibility of chitosan-poly(butylene suc...

In tissue engineering, the evaluation of the host response to the biomaterial implantation must be assessed to determine the extent of the inflammatory reaction. We studied the degradation of poly(butylene succinate) and chitosan in vitro using lipase and lysozyme enzymes, respectively. The subcutaneous implantation of the scaffolds was performed to assess tissue response. The type of inflammatory cells present...

Application of green zero-valent iron nanoparticles to the remediation of soils...

Zero-valent iron nanoparticles (nZVIs) are often used in environmental remediation. Their high surface area that is associated with their high reactivity makes them an excellent agent capable of transforming/degrading contaminants in soils and waters. Due to the recent development of green methods for the production of nZVIs, the use of this material became even more attractive. However, the knowledge of its ca...

Indirect co-cultures of stem cells with chondrocytes for cartilage tissue engin...

Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; Mesenchymal Stem Cells (MSCs) have been recognized for their ability to differentiate into cells of different tissues such as bone, cartilage or adipose tissue, and therefore might be of interest for potential therapeutic strategies. These cells are induced to differentiate by growth factors supplementation in cult...

Satisfação dos utentes com o atendimento prestado nas farmácias comunitárias

A satisfação dos utentes é considerada uma medida importante com efeitos nos resultados de cuidados de saúde. Objetivos: Determinar o grau de satisfação dos utentes com o atendimento nas farmácias comunitárias, e verificar se o grau de satisfação é igual, independentemente, da idade e do género do utente. Material e Métodos: Este estudo de caracter transversal, observacional e correlacional teve como base uma...

Chitosan – poly(butylene succinate) scaffolds and human bone marrow stromal cel...

Tissue engineering sustains the need of a three-dimensional (3D) scaffold to promote the regeneration of tissues in volume. Usually, scaffolds are seeded with an adequate cell population, allowing their growth and maturation upon implantation in vivo. Previous studies obtained by our group evidenced significant growth patterns and osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) w...

Fetal stem cells obtained from amniotic fluid and wharton's jelly expanded usin...

Extra-embryonic tissues, such as amniotic fluid (AF) and Wharton´s Jelly (WJ) of umbilical cord, offer many advantages over both embryonic and adult stem cell sources. These tissues are routinely discarded at parturition and the extracorporeal nature of these cell sources facilitates isolation, as well as the comparatively large volume and ease of physical manipulation theoretically increases the number of stem...

Gradual pore formation in natural origin scaffolds throughout subcutaneous impl...

This study used a rat subcutaneous implantation model to investigate gradual in situ pore formation in a self-regulating degradable chitosan-based material, which comprises lysozyme incorporated into biomimetic calcium phosphate (CaP) coatings at the surface to control the scaffold degradation and subsequent pore formation. Specifically, the in vivo degradation of the scaffolds, the in situ pore formation, and ...

Scaffolds based bone tissue engineering : the role of chitosan

As life expectancy increases, malfunction or loss of tissue caused by injury or disease leads to reduced quality of life in many patients at significant socioeconomic cost. Even though major progress has been made in the field of bone tissue engineering, present therapies, such as bone grafts, still have limitations. Current research on biodegradable polymers is emerging, combining these structures with osteoge...

Influence of conditioned medium over the chondrogenic differentiation of adult ...

Potential of human bone marrow derived stem cells combined with chitosan based ...

Tese de doutoramento em Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais ; Bone tissue engineering has emerged as a promising alternative in cases of bone loss, overcoming problems of rejection and donor scarcity associated to the clinical used bone grafts (autografts, allografts and xenografts). By combining threedimensional structures (3D) – scaffolds, autologous cells and growth factors, bo...