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Performance of biodegradable microcapsules of poly(butylene succinate), poly(bu...
Brunner, Cornelia T.; Baran, E. T.; Pinho, Elisabete D.; Reis, R. L.; Neves, N. M.Poly(butylene succinate) (PBSu), poly(butylene succinate-co-adipate) (PBSA) and poly(butylene terephthalate-co-adipate) (PBTA) microcapsules were prepared by the double emulsion/solvent evaporation method. The effect of polymer and poly(vinyl alcohol) (PVA) concentration on the microcapsule morphologies, drug encapsulation efficiency (EE) and drug loading (DL) of bovine serum albumin (BSA) and all-trans retinoi...
Solving cell infiltration limitations of electrospun nanofiber meshes for tissu...
Guimarães, Ana; Martins, Albino; Pinho, Elisabete D.; Faria, S.; Reis, R. L.; Neves, N. M.AIM: Utilize the dual composition strategy to increase the pore size and solve the low cell infiltration capacity on random nanofiber meshes, an intrinsic limitation of electrospun scaffolds for tissue engineering applications. MATERIALS & METHODS: Polycaprolactone and poly(ethylene oxide) solutions were electrospun simultaneously to obtain a dual composition nanofiber mesh. Selective dissolution of the poly(et...
Surface modification of a biodegradable composite by UV laser ablation : in vit...
Martins, Albino; Gang, Wu; Pinho, Elisabete D.; Rebollar, Esther; Chiussi, Stefano; Reis, R. L.; Leon, Betty; Neves, N. M.Melt blends of chitosan and biodegradable aliphatic polyester have been physically and biologically studied, presenting great potential for biomedical applications. Structurally, poly(butylene succinate)–chitosan (PBS/Cht) composite scaffolds are covered by a thin PBS layer, preventing the desired interaction of cells/tissues with the chitosan particules. In the present work, a selective and controlled ablation...
Biodegradable nanofibers-reinforced microfibrous composite scaffolds for bone t...
Martins, Albino; Pinho, Elisabete D.; Correlo, V. M.; Faria, Susana, 1972-; Marques, A. P.; Reis, R. L.; Neves, N. M.Native bone extracellular matrix (ECM) is a complex hierarchical fibrous composite structure, resulting from the assembling of collagen fibrils at several length scales, ranging from the macro to the nanoscale. The combination of nanofibers within microfibers after conventional reinforcement methodologies seems to be a feasible solution to the rational design of highly functional synthetic ECM substitutes. The ...
Degradable particulate composite reinforced with nanofibres for biomedical appl...
Pinho, Elisabete D.; Martins, A.; Araújo, J. V.; Reis, R. L.; Neves, N. M.Nanofibre-based structures and their composites are increasingly being studied for many biomedical applications, including tissue engineering scaffolds. These materials enable architectures resembling the extracellular matrix to be obtained. The search for optimized supports and carriers of cells is still a major challenge for the tissue engineering field. The main purpose of this work is to develop a novel com...
Melt-based compression-molded scaffolds from chitosan-polyester blends and comp...
Correlo, V. M.; Boesel, L. F.; Pinho, Elisabete D.; Pinto, A. R.; Silva, M. L. Alves da; Bhattacharya, Mrinal; Mano, J. F.; Neves, N. M.; Reis, R. L.Blends of chitosan and synthetic aliphatic polyesters (polybutylene succinate, polybutylene succinate adipate, polycaprolactone, and polybutylene terepthalate adipate) were compounded with and without hydroxyapatite, a bioactive mineral filler known to enhance osteoconduction. The blends and composites were compression molded with two different granulometric salt sizes (63–125 lm and 250–500 lm) having differen...
Surface modification of electrospun polycaprolactone nanofiber meshes by plasma...
Martins, Albino; Pinho, Elisabete D.; Faria, Susana, 1972-; Pashkuleva, I.; Marques, A. P.; Reis, R. L.; Neves, N. M.A critical aspect in the development of biomaterials is the optimization of their surface properties to achieve an adequate cell response. In the present work, electrospun polycaprolactone nanofiber meshes (NFMs) are treated by radio-frequency (RF) plasma using different gases (Ar or O2), power (20 or 30 W), and exposure time (5 or 10 min). Morphological and roughness analysis show topographical changes on the ...
Surface controlled biomimetic coating of polycaprolactone nanofiber meshes to b...
Araújo, J. V.; Martins, Albino; Leonor, I. B.; Pinho, Elisabete D.; Reis, R. L.; Neves, N. M.The aim of this work was to develop novel electrospun nanofiber meshes coated with a biomimetic calcium phosphate (BCP) layer that mimics the extracellular microenvironment found in the human bone structure. Poly(!-caprolactone) (PCL) was selected because of its well-known medical applications, its biodegradability, biocompatibility and its susceptibility to partial hydrolysis by a straightforward alkaline trea...
Water absorption and degradation characteristics of chitosan-based polyesters a...
Correlo, V. M.; Pinho, Elisabete D.; Pashkuleva, I.; Bhattacharya, Mrinal; Neves, N. M.; Reis, R. L.Blends of chitosan and biodegradable synthetic aliphatic polyesters (polycaprolactone, poly-(butylene succinate), poly[(butylene succinate)-co-adipate], poly[(butylene terephthalate)-co-adipate], and poly(lactic acid)) were injection-molded. These samples were immersed in isotonic solution at 37ºC for a period of 60 d. The water uptake and the degradation properties, as measured by the loss in tensile strength,...
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