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Blood flow in a bifurcation and confluence microchannel : the effectof the cell...
Pinho, Diana; Bento, David; Rodrigues, Raquel; Fernandes, Carla S.; Garcia, Valdemar; Lima, R.A few detailed studies have been performed in complex in vitro microvascular networks composed by bifurcations and confluences. The main purpose of the present work is to numerically simulate the flow of two distinct fluids through bifurcation and confluence geometries, i. e red blood cells (RBCs) suspended in Dextran40 with about 14% of heamatocrit and pure water. The simulations of pure water and RBCs flows w...
Extensional flow-based microfluidic device: deformability assessment of red blo...
Faustino, Vera; Pinho, Diana; Yaginuma, T.; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Lima, R.Red blood cell (RBC) deformability has become one of the important factors to assess blood and cardiovascular diseases. The interest on blood studies have promoted a development of various microfluidic devices that treat and analyse blood cells. Recent years, besides the RBC deformability assessment, these devices are often applied to cancer cell detection and isolation from the whole blood. The devices for can...
Blood flow in a bifurcation and confluence microchannel : effect of the cell-...
Pinho, Diana; Bento, David; Rodrigues, Raquel; Fernandes, Carla S.; Garcia, Valdemar; Lima, R.A few detailed studies have been performed in complex in vitro microvascular networks composed by bifurcations and confluences. The main purpose of the present work is to numerically simulate the flow of two distinct fluids through bifurcation and confluence geometries, i. e red blood cells (RBCs)suspended in Dextran40 with about 14% of heamatocrit and pure water. The simulations of pure water and RBCs flows we...
Visualization and measurement of red blood cells flowing in microfluidic devices
Rodrigues, Raquel; Pinho, Diana; Faustino, Vera; Yaginuma, T.; Bento, David; Fernandes, Carla S.; Garcia, Valdemar; Lima, R.Several experimental techniques were performed in the past years using in vitro environments, in an attempt to not only understand the blood flow behaviour in microcirculation but also develop microfluidic devices as an alternative clinical methodology to detect blood diseases. Hence, the visualization and measurement of red blood cells (RBCs) flowing in a microfluidic device are important to provide not only e...
Cell-free layer (CFL) measurements in complex geometries: contractions and bifu...
Novais, Susana; Pinho, Diana; Bento, David; Pinto, Elmano; Yaginuma, Tomoko; Fernandes, Carla S.; Garcia, Valdemar; Pereira, Ana I.; Lima, JoséIn this chapter we discuss the cell-free layer (CFL) developed adjacent to the wall of microgeometries containing complex features representative of the microcirculation, such as contractions, expansions, bifurcations and confluences. The microchannels with the different geometries were made of polydimethylsiloxane (PDMS) and we use optical techniques to evaluate the cell-free layer for red blood cells (RBC) su...
Desenvolvimento de um microdispositivo biomédico para a separação de células sa...
Novais, Susana; Pinho, Diana; Pereira, Ana I.; Mujika, Maite; Arana, Sergio; Lima, R.Neste trabalho procedeu-se ao desenho e implantação de um dispositivo biomédico, com capacidade de realizar a separação das células sanguíneas da camada de plasma. Numa primeira fase do trabalho realizou-se o desenho e fabricação do dispositivo, através da técnica de litografia suave. A segunda fase consistiu no estudo do escoamento sanguíneo com o objetivo de analisar o efeito das constrições na variação da es...
Desenvolvimento de um microdispositivo biomédico para a separação de células sa...
Novais, Susana; Pinho, Diana; Pereira, Ana I.; Mujika, Maite; Arana, Sergio; Lima, R.Neste trabalho procedeu-se ao desenho e implantação de um dispositivo biomédico, com capacidade de realizar a separação das células sanguíneas da camada de plasma. Numa primeira fase do trabalho realizou-se o desenho e fabricação do dispositivo, através da técnica de litografia suave. A segunda fase consistiu no estudo do escoamento sanguíneo com o objetivo de analisar o efeito das constrições na variação da es...
Cell-free layer measurements in a bifurcation microchannel : comparison between...
Bento, David; Pinho, Diana; Pinto, Elmano; Yaginuma, Tomoko; Correia, Teresa Montenegro; Lima, José; Pereira, Ana I.; Lima, R.In the present work, in vitro blood flowing through a bifurcation microchannel was studied. The aim was to measure the Trajectories of the cell-free layer (CFL) by using different methods, i. e., a manual and two automatic methods.
Cell-free layer measurements in a bifurcation microchannel : comparison between...
Bento, David; Pinho, Diana; Pinto, Elmano; Yaginuma, Tomoko; Correia, Teresa Montenegro; Lima, José; Pereira, Ana I.; Fernandes, Carla S.O artigo deve também estar associado ao Departamento de Electrotécnia, Tecnologia Mecânica e Química ; In the present work, in vitro blood flowing through a bifurcation microchannel was studied. The aim was to measure the Trajectories of the cell-free layer (CFL) by using different methods, i. e., a manual and two automatic methods.
Measurement of red blood cells deformation index in a hyperbolic microchannel
Faustino, V.; Pinho, Diana; Yaginuma, Tomoko; Calhelha, Ricardo C.; Man-Kim, Gyeong; Arana, Sergio; Lima, R.; Ferreira, Isabel C.F.R.; Oliveira, M.S.N.A hyperbolic microchannel was used for the purpose of observing the deformation index of the erythrocytes after contact with human tumour cell line (HCT-15 - colon carcinoma). Three cases were compared and the results showed that the deformation index decreases when erythrocytes are in contact with HCT-15.
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