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Functional characterization and evolution ofPTH/PTHrP receptors: insights from ...
Pinheiro, Pedro L. C.; Cardoso, João; Power, Deborah; Canario, Adelino V. M.The parathyroid hormone (PTH)-family consists of a group of structurally related factors that regulate calcium and bone homeostasis and are also involved in development of organs such as the heart, mammary gland and immune system. They interact with specific members of family 2 B1 G-protein coupled receptors (GPCRs), which have been characterised in teleosts and mammals. Two PTH/PTHrP receptors, PTH1R and PTH2R...
Gene structure, transcripts and calciotropic effects of the PTH family of pepti...
Pinheiro, Pedro L. C.; Cardoso, J. C. R.; Gomes, Ana S.; Fuentes, Juan; Power, Deborah; Canario, Adelino V. M.Background: Parathyroid hormone (PTH) and PTH-related peptide (PTHrP) belong to a family of endocrine factors that share a highly conserved N-terminal region (amino acids 1-34) and play key roles in calcium homeostasis, bone formation and skeletal development. Recently, PTH-like peptide (PTH-L) was identified in teleost fish raising questions about the evolution of these proteins. Although PTH and PTHrP have be...
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