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Up-regulation of neuropeptide Y levels and modulation of glutamate release thro...
Silva, Ana P.; Xapelli, Sara; Pinheiro, Paulo S.; Ferreira, Raquel; Lourenço, Joana; Cristóvão, Armando; Grouzmann, Eric; Cavadas, CláudiaKainate-induced epilepsy has been shown to be associated with increased levels of neuropeptide Y (NPY) in the rat hippocampus. However, there is no information on how increased levels of this peptide might modulate excitation in kainate-induced epilepsy. In this work, we investigated the modulation of glutamate release by NPY receptors in hippocampal synaptosomes isolated from epileptic rats. In the acute phase...
Activation of neuropeptide Y receptors is neuroprotective against excitotoxicit...
Silva, Ana P.; Pinheiro, Paulo S.; Carvalho, Arsélio P.; Carvalho, Caetana M.; Jakobsen, Birthe; Zimmer, Jens; Malva, João O.Glutamate and NPY have been implicated in hippocampal neuropathology in temporal lobe epilepsy. Thus, we investigated the involvement of NPY receptors in mediating neuroprotection against excitotoxic insults in organotypic cultures of rat hippocampal slices. Exposure of hippocampal slice cultures to 2 μM AMPA (α-amino-3-hydroxy-5-methyl-isoxazole-4- propionate) induced neuronal degeneration, monitored by propid...
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