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Subcellular localization of adenosine A1 receptors in nerve terminals and synap...

Adenosine is a neuromodulator in the CNS that mainly acts through pre- and postsynaptic A1 receptors to inhibit the release of excitatory neurotransmitters and NMDA receptor function. This might result from a highly localized distribution of A1 receptors in the active zone and postsynaptic density of CNS synapses that we now investigated in the rat hippocampus. The binding density of the selective A1 receptor a...