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A comprehensive assessment of the transcriptome of cork oak (Quercus suber) thr...

Background: Cork oak (Quercus suber) is one of the rare trees with the ability to produce cork, a material widely used to make wine bottle stoppers, flooring and insulation materials, among many other uses. The molecular mechanisms of cork formation are still poorly understood, in great part due to the difficulty in studying a species with a long life-cycle and for which there is scarce molecular/genomic inform...

Assessment of the Geographic Origins of Pinewood Nematode Isolates via Single N...

The pinewood nematode, Bursaphelenchus xylophilus, is native to North America but it only causes damaging pine wilt disease in those regions of the world where it has been introduced. The accurate detection of the species and its dispersal routes are thus essential to define effective control measures. The main goals of this study were to analyse the genetic diversity among B. xylophilus isolates from different...

Professional Risk Management: The Challenge of Population Ageing

Searching for resistance genes to Bursaphelenchus xylophilus using high through...

Background: Pine wilt disease (PWD), caused by the pinewood nematode (PWN; Bursaphelenchus xylophilus), damages and kills pine trees and is causing serious economic damage worldwide. Although the ecological mechanism of infestation is well described, the plant’s molecular response to the pathogen is not well known. This is due mainly to the lack of genomic information and the complexity of the disease. High thr...

Multi-object tracking in video sequences

Tese de mestrado integrado. Engenharia Electrotécnica e de Computadores. Faculdade de Engenharia. Universidade do Porto. 2010

Searching for resistance genes to the PWN using SSH and high throughput screening

Sistema computacional para o estudo da estrutura primária e redesenho de genes

Um dos maiores avanços científicos do século XX foi o desenvolvimento de tecnologia que permite a sequenciação de genomas em larga escala. Contudo, a informação produzida pela sequenciação não explica por si só a sua estrutura primária, evolução e seu funcionamento. Para esse fim novas áreas como a biologia molecular, a genética e a bioinformática são usadas para estudar as diversas propriedades e funcionamento...

Codon-triplet context unveils unique features of the Candida albicans protein c...

BACKGROUND: The evolutionary forces that determine the arrangement of synonymous codons within open reading frames and fine tune mRNA translation efficiency are not yet understood. In order to tackle this question we have carried out a large scale study of codon-triplet contexts in 11 fungal species to unravel associations or relationships between codons present at the ribosome A-, P- and E-sites during each de...

Large scale comparative genomics of codon context

The efficiency of protein synthesis is highly dependent on codon usage and codon context. Indeed, the choice of particular synonymous codons is constrained by neighbour codons (codon context) to optimize mRNA decoding speed and accuracy. This is related to spatial (steric) effects created by the need to accommodate 3 tRNAs in the ribosome A-, P- and E-sites. Since these tRNAs interact with each other, with thei...

Sistema de rastreio de doenças metabólicas

O objectivo principal deste trabalho é desenhar e implementar um sistema de suporte à decisão, apoiado num conjunto de ferramentas matemáticas e estatísticas, que permita rastrear doenças metabólicas em recém-nascidos. O sistema terá que reduzir ao máximo o número recém-nascidos com diagnósticos de falsos positivos e negativos. Para tal, o sistema apoia-se na análise dos valores obtidos em recém-nascidos saudáv...