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Root resorption in orthodontics - Genetic susceptibility?

Root Resorption in Orthodontics - Genetic Susceptibility?

OBJECTIVES: External root resorption (ERR) is a condition that can be observed in association with orthodontic treatment. The etiology of root resorption is complex, related with several factors. Some inflammatory mediators, controlled by specific genes, have been associated with bone resorption and in the recruitment of osteoclasts during orthodontic movement (Lee et al., 2007; Abass et al., 2008; Bastos et al...

Conjugation of human topoisomerase 2A with small ubiquitin-like modifiers 2/3 i...

Type 2 topoisomerases, in particular the A isoform in human cells, play a key role in cohesion and sister chromatid separation during mitosis. These enzymes are thus vital for cycling cells and are obvious targets in cancer chemotherapy. Evidence obtained in yeast and Xenopus model systems indicates that conjugation of topoisomerase 2 with small ubiquitin-like modifier (SUMO) proteins is required for its mitoti...