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New sustained release of Zidovudine Matrix tablets − cytotoxicity toward Caco-2...
Santos, Jucimary V.; Pina, Maria Eugénia T.; Marques, M. P. M.; Batista de Carvalho, Luís A. E.Objective: The aim of this study was to adjust the zidovudine (AZT) release from solid tablets to an ideal profile, by developing matrices comprising swellable polymers with nonswellable ones. Methods: Directly compressed matrices comprised different ratios of hydroxypropylmethylcellulose K15M and K100M, ethylcellulose, and methacrylic acid (Eudragit® RS PO and Eudragit® RL PO) were prepared. Technological char...
Data: 2013
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Origem: Estudo Geral - Universidade de Coimbra
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