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Development of TAL effector: recombinase fusion proteins for genome engineering

Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2013 ; Genome engineering is currently entering the phase of genetic manipulation in vivo. Several important discoveries have made this progress possible, such as the development of site-specific recombinases (SSRs) and the discovery of TAL effector (TALE) proteins a novel type of DNA-binding proteins. SS...