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Augmented renal clearance in septic patients and implications for vancomycin op...

Baptista, JP; Sousa, E; Martins, PJ; Pimentel, JM

The aim of this study was to evaluate the effect of augmented renal clearance (ARC) on vancomycin serum concentrations in critically ill patients. This prospective, single-centre, observational, cohort study included 93 consecutive, critically ill septic patients who started treatment that included vancomycin by continuous infusion, admitted over a 2-year period (March 2006 to February 2008). ARC was defined as...


Transverse coloplasty pouch and colonic J-pouch for rectal cancer: a comparativ...

Pimentel, JM; Duarte, A; Gregório, C; Souto, P; Patrício, J

OBJECTIVES: The introduction of the colonic J-pouch has markedly improved the functional outcome of restorative rectal cancer surgery. However colonic J-pouch surgery can be problematic and may present some late evacuatory problems. To overcome these limitations a novel pouch has been proposed: the transverse coloplasty pouch. The purpose of our study was to compare the functional outcomes of these two differen...


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