INTRODUCTION: Epidemiological studies concerning HCV genotypic distribution in the Brazilian Amazon are scarce. Thus, this study determined the patterns of distribution of HCV genotypes among different exposure categories in the State of Pará, Brazilian Amazon. METHODS: A cross-sectional study was conducted on 312 HCV-infected individuals belonging to different categories of exposure, who were attended at the H...
Given the scarcity of epidemiological information on hepatitis C virus (HCV) infection in Northern Brazil, we determined the prevalence and genotypic frequency in blood donors in the state of Pará (PA). Blood samples from all of the blood donors at the Fundação HEMOPA (blood bank of PA) from 2004-2006 were screened for the presence of antibodies to anti-HCV and samples seroreactive to anti-HCV were further test...
We determined the risk factors for HCV infection in blood donors in the State of Pará, Northern Brazil. We examined 256 blood donors seen at the Blood Bank of Pará State between 2004 and 2006. They were divided into two groups, depending on whether they were infected with HCV or not; 116 donors were infected with HCV, while the other 140 were free of infection. The HCV-RNA was detected by real-time PCR. All of ...
An ofloxacin-selective electrode based on incorporation of a ofloxacin-tetrakis[3,5- bis(trifluoromethyl)phenyl]borate ion-pair complex in a poly(vinyl chloride) membrane was developed. The sensor displayed a Nernstian response over a wide concentration range (7×10-6–1×10-2 mol L-1) with a slope of 54.9 ± 1.3 mV per decade of concentration, a detection limit of 4×10-6 mol L-1 and adequate selectivity toward som...
A voltametria de redissolução com eléctrodos de filme de mercúrio (mFes) constitui uma ferramenta poderosa para a monitorização de metais vestigiais. recentemente, os eléctrodos de filme de bismuto (bFes) apareceram como uma alternativa vantajosa, apresentando uma toxicidade negligenciável para o ambiente. neste trabalho são propostas duas novas metodologias (em batch e em fluxo), que se baseiam na realização d...
As “i jornadas sobre intoxicações - intoxicações, interacções e reacções Adversas a medicamentos” reuniram alguns profissionais do nosso país que partilharam experiências e conhecimentos com o objectivo de contribuir para minimizar a incidência e/ou gravidade das reacções adversas a fármacos. neste artigo pretende-se compilar a informação partilhada durante as jornadas e aprofundá-la, contribuindo para que os p...
Dissertação de Doutoramento em Química Analítica apresentada à Faculdade de Farmácia da Universidade do Porto
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