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Lynch Syndrome without mutation of Mismatch Repair Genes: The other face of the...
Faria, Gil; Hospital de São João, EPE; Serviço de Cirurgia Geral Faculdade de Medicina da Universidade do Porto, PortugalBackground: Lynch Syndrome (LS) is the most frequent form of hereditary colorectal cancer (CRC) and derives from germinative mutations in the mismatch repais genes (MMR). The clinical diagnosis is based on Amsterdam criteria (AC) but definitive diagnostic is based on the identification of a MMR gene mutation. Of these, MLH1 and MSH2 are the most frequent, followed by MSH6 and rarely by other genes (PMS1 and PMS...
Physicochemical characterization of orally-active meglumine antimoniate/beta-cy...
Martins,P. S.; Ribeiro,R. R.; Bahia,A. P. C; M. Neto,R. L.; Frézard,F.; Pimenta,A. M. C.; Melo,A. L.; Le Moyec,L.; Demicheli,C.β-cyclodextrin (β-CD) is widely used as a component of pharmaceutical formulations, classically to improve the solubility and oral bioavailability of poorly water-soluble drugs through formation of drug/β-CD inclusion complexes. Unexpectedly, the association of the highly water-soluble drug meglumine antimoniate (MA) with β-CD turned this antimonial compound orally-active in a murine model o...
Spectrophotometric study of the chromium(III)/azide system in the ultraviolet r...
Lourenço,L. M.; Martins,F. G.; Balbo,V. R.; Pimenta,A. C.; Castro,J. R. M.; Andrade,J. F.A sensitive and alternative method for the spectrophotometric determination of chromium(III) based on the formation of chromium(III)/azide complexes was established by investigating a new band in the ultraviolet region. The best experimental conditions for the analytical determination of this metallic ion were: ligand and perchloric acid analytical concentration = 493 and 12.0 mmol L-1, respectively; aqueous me...
Spectrophotometric study of iron oxidation in the iron(II)/thiocyanate/acetone ...
Martins,F. G.; Andrade,J. F.; Pimenta,A. C.; Lourenço,L. M.; Castro,J. R. M.; Balbo,V. R.The possibility of using thiocyanate to determine iron(II) and/or iron(III) in water-acetone mixture has been re-examined as part of a systematic and comparative study involving metallic complexes of pseudohalide ligands. Some parameters that affect the complete oxidation of the ferrous cations, their subsequent complexation and the system stability have been studied to optimize the experimental conditions. Our...
Clinical, multicentric, and open study to evaluate the efficacy of and toleranc...
PALHA, A.P.; GOMES, F.A.; MARTINS, A.S.; PIMENTA, A.; NEVES, J.; GONCALVES, R.; RAMOS, L.; ABRANTES, P.; CANHAO, A.; SANTOS, G.; CARVALHO, L.F.Acta Med Port. 2002 Jul-Aug;15(4):249-56. [Clinical, multicentric, and open study to evaluate the efficacy of and tolerance to sildenafil in patients with erectile dysfunction] [Article in Portuguese] Palha AP, Gomes FA, Martins AS, Pimenta A, Neves J, Gonçalves R, Ramos L, Abrantes P, Canhão A, Santos G, Carvalho LF, Soares J, Lima E, Rosa G. Serviço de Psiquiatria e Urologia do Hospital de S. João, Instutu...
Estudo clínico, multicêntrico, aberto para avaliar a eficácia e a tolerância do...
Palha, AP; Gomes, A; Martins, AS; Pimenta, A; Neves, J; Gonçalves, R; Ramos, L; Abrantes, P; Canhão, A; Santos, G; Carvalho, LF; Soares, J; Lima, EErectile dysfunction (ED), defined by the Impotence-NIH Consensus Conference as the "persistent inability to achieve and/or maintain erection sufficient for satisfactory sexual activity" affect more than 100 million men worldwide, at particular severity levels. The global prevalence of ED is estimated to affect about 10%, but has been found to increase significantly with age (39% in men 40 years of age and 67% ...
Neoplasia renal con extensión a la vena cava
Barradas, D.; Araújo, D.; Pimenta, A.La neoplasia renal con extensión a la vena cava es relativamente rara (4-10%). Cualquiera que sea la terapia coadjuvante (radioterapia, hormonal, quimioterapia e inmunoterapia), la exéresis completa del trombo tumoral de la vena cava continúa siendo la mejor forma de tratamiento. El valor pronóstico de la extensión cefálica de un trombo tumoral en la vena cava inferior en enfermos con carcinoma de células renal...
Pelvic lipomatosis
Prisco, R.M.; Peres, A.M.; Macedo, F.C.; Lhamas, A.P.; Araújo, D.R.; Pimenta, A.F.; Milheiro, A.A.Actas Urol Esp. 1998 Sep;22(8):717-20. [Pelvic lipomatosis] [Article in Spanish] Prisco RM, Peres AM, Macedo FC, Lhamas AP, Araújo DR, Pimenta AF, Milheiro AA. Servicio de Urología, Hospital Geral de Santo António, Porto, Portugal. Abstract Pelvian lipomatosis is a proliferative process of fatty tissue in the perivesical and perirectal pelvian space. The etiology is unknown and some authors consider that in rea...
Cryptorchidism. The clinical implications.
Estevão-Lima, .; Unidade de Andrologia, Hospital Geral de Santo António, Porto.; Pimenta, AThis paper briefly reviews the literature on testicular descent and management implications for cryptorchidism. At present, we believe that descent of the testes in humans is a complex event mediated by both hormonal and mechanical factors. There is now good evidence that testicular descent occurs in two morphologic and hormonally distinct phases. Relative "transabdominal migration", which occurs in the 8th and...
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