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Relationships between transcription, silver staining and chromatin organization...
Caperta, A.; Neves, Nuno; Viegas, Wanda; Pikaard, Craig S.; Preuss, SashaSummary. The nucleolar organizer regions (NORs) are composed of hundreds of rRNA genes, typically spanning several megabases. Cytologically, NORs include regions that are highly condensed and regions that are decondensed, the latter corresponding to regions at which associated proteins stain intensively with silver (Ag-NORs) and where active rRNA gene transcription is thought to occur. To test the relationship ...
A concerted DNA methylation/histone methylation switch regulates rDNA gene dosa...
Silva, Manuela; Viegas, Wanda; Lawrence, Richard J.; Early, Keith; Pontes, Olga; Chen, Z.; Neves, Nuno; Pikaard, Craig.S.Eukaryotes regulate the effective dosage of their ribosomal RNA (rRNA) genes, expressing fewer than half of the genes at any one time. Likewise, genetic hybrids displaying nucleolar dominance transcribe rRNA genes inherited from one parent but silence the other paraental set.We show that rRNA gene dosage control and nucleolar dominance utilize a common mechanism
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