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Monoclonal antibody raised against PNAG has variable effects on static S. epide...

Global transcriptomic analysis of dormancy within Staphylococcus epidermidis bi...

Whole transcriptome analysis of Staphylococcus epidermidis biofilms upon contac...

Staphylococcus epidermidis is commonly associated with foreign body infections due to its ability to form biofilms on the surface of indwelling medical devices. Understanding how the biofilms form on the top of devices and interact with the host, particularly, with human blood components, is of great interest. Here we assessed the whole transcriptome of S. epidermidis biofilms upon contact with human blood. Est...

Staphylococcus epidermidis biofilm lifecycle and its virulence: from plantkonic...

Staphylococcus epidermidis biofilms with higher proportions of dormant bacteria...

Molecular basis for preferential protective efficacy of antibodies directed to ...

Poly-N-acetyl-glucosamine (PNAG) is a staphylococcal surface polysaccharide influencing biofilm formation that is also under investigation for its vaccine potential. Antibodies that bind to PNAG with either low (<15%) or high (>90%) levels of acetate are superior at opsonic and protective activity compared with antibodies that bind to PNAG with only high levels (>70%) of acetate. PNAG is synthesized by four pro...

Protection against Escherichia coli infection by antibody to the Staphylococcus...

Poly-N-acetylglucosamine (PNAG) is a surface polysaccharide produced by Staphylococcus aureus and Staphyloccus epidermidis and is an effective target for opsonic and protective Ab for these two organisms. Recently, it has been found that Escherichia coli produces an exo-polysaccharide, designated polyglucosamine, that is biochemically indistinguishable from PNAG. We analyzed 30 E. coli strains isolated from uri...

Comparative antibody-mediated phagocytosis of Staphylococcus epidermidis cells ...

Staphylococcus epidermidis is an important cause of nosocomial infections. Virulence is attributable to elaboration of biofilms on medical surfaces that protect the organisms from immune system clearance. Even though leukocytes can penetrate biofilms, they fail to phagocytose and kill bacteria. The properties that make biofilm bacteria resistant to the immune system are not well characterized. In order to bette...

Use of confocal laser scan microscopy (CLSM) to evaluate S. epidermidis biofilm...

Staphylococcus epidermidis is the major organism causing nosocomial infections associated with the formation of a biofilm on medical devices. The major constituent of S. epidermidis biofilm matrix is the polysaccharide PNAG, synthesized by the proteins encoded in the icaADBC locus. CLSM low energy lasers allows the observation of living cells, and its penetration ability renders detailed tridimensional images o...

Effects of Growth in the Presence of Subinhibitory Concentrations of Dicloxacil...

Low concentrations of antibiotics can inhibit microbial adherence to medical device surfaces. However, little is known about the changes that occur in the physiology of bacteria within biofilms formed in the presence of subinhibitory (sub-MIC) concentrations of antibiotics. In this study, the densities and matrix compositions of biofilms formed by two coagulase-negative Staphylococcus species in the absence and...