Encontrados 4 documentos, a visualizar página 1 de 1
Electrochemical behaviour of 2,8-dihydroxyadenine at a glassy carbon electrode
Diculescu, Victor C.; Piedade, José António P.; Oliveira-Brett, Ana MariaThe electrochemical behaviour of 2,8-dihydroxyadenine (2,8-DHA)- the main adenine oxidation product- has been investigated over a wide pH range at a glassy carbon electrode (GCE) using cyclic, differential pulse and square wave voltammetry. ; http://www.sciencedirect.com/science/article/B6W72-4K0FG20-1/1/98da49a6d6213ae493b4562dd5599e49
Electrochemical determination of 8-oxoguanine in the presence of uric acid
Rebelo, Isabel; Piedade, José António P.; Brett, Ana Maria OliveiraThe electrochemical oxidation of 8-oxoguanine (8-oxoG) in the presence of uric acid (UA) was studied by differential pulse voltammetry over a wide pH range (1-12). The results showed that both compounds follow a pH-dependent oxidation mechanism that involves two electrons and two protons corresponding to reversible charge transfer reactions. The difference between the peak potential for the oxidation of each an...
Development of an HPLC method with electrochemical detection of femtomoles of 8...
Rebelo, Isabel A.; Piedade, José António P.; Oliveira-Brett, Ana MariaA selective method based on high performance liquid chromatography with electrochemical detection (HPLC-ECD) was developed to enable simultaneous detection of 8-oxo-7,8-dihydroguanine (8-oxoGua) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo), products of DNA oxidative damage, in the presence of uric acid (UA), a strong interferent in their electrochemical detection. The method developed consists of HPLC is...
Anodic voltammetry and AFM imaging of picomoles of adriamycin adsorbed onto car...
Oliveira-Brett, Ana Maria; Piedade, José António P.; Chiorcea, Ana-MariaAdriamycin adsorbs strongly and irreversibly onto surfaces and this enabled electrochemical detection of in situ adriamycin oxidative damage to DNA. The adsorption of adriamycin onto glassy carbon and highly oriented pyrolytic graphite (HOPG) electrodes was studied by voltammetry and mode atomic force microscopy (MAC). At a glassy carbon electrode (GCE), the adsorbate has similar voltammetric behaviour to adria...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||