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Gellan gum : a new biomaterial for cartilage tissue engineering applications

Oliveira, João T.; Martins, L.; Picciochi, R.; Malafaya, P. B.; Sousa, R. A.; Neves, N. M.; Mano, J. F.; Reis, R. L.

Gellan gum is a polysaccharide manufactured by microbial fermentation of the Sphingomonas paucimobilis microorganism, being commonly used in the food and pharmaceutical industry. It can be dissolved in water, and when heated and mixed with mono or divalent cations, forms a gel upon lowering the temperature under mild conditions. In this work, gellan gum hydrogels were analyzed as cells supports in the context o...


Gellan gum injectable hydrogels for cartilage tissue engineering applications :...

Oliveira, João T.; Santos, T. C.; Martins, L.; Picciochi, R.; Marques, A. P.; Castro, António G.; Neves, N. M.; Mano, J. F.; Reis, R. L.

Gellan gum is a polysaccharide that we have previously proposed for applications in the cartilage tissue engineering field. In this work, gellan gum hydrogels were tested for their ability to be used as injectable systems using simple processing methods, able to deliver and maintain chondrocytes by in situ gelation, and support cell viability and production of extracellular matrix (ECM). Rheological measurement...


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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia