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Nanostructured polymeric coatings based on chitosan and dopamine-modified hyalu...
Neto, Ana I.; Cibrão, Ana; Correia, Clara R.; Carvalho, Rita R.; Luz, Gisela; Ferrer, Glória G.; Botelho, Gabriela; Picart, Catherine; Alves, N. M.In a marine environment, specific proteins are secreted by mussels and used as a bioglue to stick to a surface. These mussel proteins present an unusual amino acid 3,4-dihydroxyphenylalanine (known as DOPA). The outstanding adhesive properties of these materials in the sea harsh conditions have been attributed to the presence of the catechol groups present in DOPA. Inspired by the structure and composition of t...
Free-standing polyelectrolyte membranes made of chitosan and alginate
Caridade, S. G.; Monge, Claire; Gilde, Flora; Boudou, Thomas; Mano, J. F.; Picart, CatherineFree-standing films have increasing applications in the biomedical field as drug delivery systems for wound healing and tissue engineering. Here, we prepared free-standing membranes by the layer-by-layer assembly of chitosan and alginate, two widely used biomaterials. Our aim was to produce a thick membrane and to study the permeation of model drugs and the adhesion of muscle cells. We first defined the optimal...
Secondary structure of rhBMP-2 in a protective biopolymeric carrier material
Gilde, Flora; Maniti, Ofélia; Guillot, Raphael; Mano, J. F.; Logeart-Avramoglou, Delphine; Sailhan, Frédéric; Picart, CatherineEfficient delivery of growth factors is one of the great challenges of tissue engineering. Polyelectrolyte multilayer films (PEM) made of biopolymers have recently emerged as an interesting carrier for delivering recombinant human bone morphogenetic protein 2 (rhBMP-2 noted here BMP-2) to cells in a matrix-bound manner. We recently showed that PEM made of poly(l-lysine) and hyaluronan (PLL/HA) can retain high a...
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