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The role of glycoprotein 130 family of cytokines in fetal rat lung development
Silva, Cristina Nogueira; Piairo, Paulina C.; Dias, Emanuel Carvalho; Veiga, Carla; Moura, Rute S.; Pinto, Jorge CorreiaThe glycoprotein 130 (gp130) dependent family of cytokines comprises interleukin-6 (IL-6), IL-11, leukemia inhibitory factor (LIF), cardiotrophin-like cytokine (CLC), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and oncostatin M (OSM). These cytokines share the membrane gp130 as a common signal transducer. Recently, it was demonstrated that IL-6 promotes, whereas LIF inhibits fetal lung branching...
Local fetal lung renin-angiotensin system as a target to treat congenital diaph...
Silva, Cristina Nogueira; Dias, Emanuel Carvalho; Piairo, Paulina C.; Nunes, Susana; Baptista, Maria João Ribeiro Leite; Moura, Rute S.Antenatal stimulation of lung growth is a reasonable approach to treat congenital diaphragmatic hernia (CDH), a disease characterized by pulmonary hypoplasia and hypertension. Several evidences from the literature demonstrated a possible involvement of renin-angiotensin system (RAS) during fetal lung development. Thus, the expression pattern of renin, angiotensin-converting enzyme, angiotensinogen, type 1 (AT1)...
Leukemia inhibitory factor in rat fetal lung development : expression and funct...
Silva, Cristina Nogueira; Piairo, Paulina C.; Dias, Emanuel Carvalho; Peixoto, Francisca; Moura, Rute S.; Pinto, Jorge CorreiaConceived and designed the experiments: CN-S EC-D JC-P. Performed the experiments: CN-S PP EC-D FOP RSM. Analyzed the data: CN-S PP JC-P. Wrote the paper: CN-S PP RSM JC-P. ; Leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) are members of the family of the glycoprotein 130 (gp130)-type cytokines. These cytokines share gp130 as a common signal transducer, which explains why they show some functional re...
The apelinergic system in the developing lung : expression and signaling
Piairo, Paulina C.; Moura, Rute S.; Silva, Cristina Nogueira; Pinto, Jorge CorreiaApelin and its receptor APJ constitute a signaling pathway best recognized as an important regulator of cardiovascular homeostasis. This multifunctional peptidergic system is currently being described to be involved in embryonic events which extend into vascular, ocular and heart development. Additionally, it is highly expressed in pulmonary tissue. Therefore, the aim of this study was to investigate the role o...
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