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The role of lipase and alpha-amylase in the degradation of starch/poly(epsilon-...
Martins, Ana M.; Pham, Q. P.; Malafaya, P. B.; Sousa, R. A.; Gomes, Manuela E.; Raphael, R. M.; Kasper, F. Kurtis; Reis, R. L.; Mikos, Antonios G.The present work studies the influence of hydrolytic enzymes (a-amylase or lipase) on the degradation of fiber mesh scaffolds based on a blend of starch and poly(e-caprolactone) (SPCL) and the osteogenic differentiation of osteogenic medium–expanded rat bone marrow stromal cells (MSCs) and subsequent formation of extracellular matrix on these scaffolds under static culture conditions. The biodegradation profile...
Natural stimulus responsive scaffolds/cells for bone tissue engineering : influ...
Martins, Ana M.; Pham, Q. P.; Malafaya, P. B.; Raphael, R. M.; Kasper, F. Kurtis; Reis, R. L.; Mikos, Antonios G.This work proposes the use of nonporous, smart, and stimulus responsive chitosan-based scaffolds for bone tissue engineering applications. The overall vision is to use biodegradable scaffolds based on chitosan and starch that present properties that will be regulated by bone regeneration, with the capability of gradual in situ pore formation. Biomimetic calcium phosphate (CaP) coatings were used as a strategy t...
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