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Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis o...
Perfeito, Rita; Cunha-Oliveira, Teresa; Rego, Ana CristinaParkinson disease (PD) is a chronic and progressive neurological disease associated with a loss of dopaminergic neurons. In most cases the disease is sporadic but genetically inherited cases also exist. One of the major pathological features of PD is the presence of aggregates that localize in neuronal cytoplasm as Lewy bodies, mainly composed of α-synuclein (α-syn) and ubiquitin. The selective degeneration of ...
Interplay between Alpha-Synuclein and Oxidative Stress in Parkinson´s Disease C...
Perfeito, Rita Catarina GonçalvesParkinson’s disease (PD) is the most common motor and age-related neurodegenerative disorder affecting more than 1% of the population above age 65. Neurologically, PD patients present symptoms of progressive deterioration of tremor, rigidity of movements, bradykinesia and postural instability. The major neuropathological features of the disease are characterized by a progressive degeneration of dopaminergic neu...
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