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Evaluation of the role of glutathione in the lead-induced toxicity in saccharom...
Perez, Rita R.; Sousa, Cátia A.; Vankeersbilck, Thomas; Machado, Manuela D.; Soares, Eduardo V.The effect of intracellular reduced glutathione (GSH) in the lead stress response of Saccharomyces cerevisiae was investigated. Yeast cells exposed to Pb, for 3 h, lost the cell proliferation capacity (viability) and decreased intracellular GSH level. The Pb-induced loss of cell viability was compared among yeast cells deficient in GSH1 (∆gsh1) or GSH2 (∆gsh2) genes and wild-type (WT) cells. When exposed to Pb,...
Evaluation of the role of glutathione in the lead-induced toxicity in Saccharom...
Perez, Rita R.; Sousa, Cátia A.; Vankeersbilck, Thomas; Machado, Manuela D.; Soares, Eduardo V.The effect of intracellular reduced glutathione (GSH) in the lead stress response of Saccharomyces cerevisiae was investigated. Yeast cells exposed to Pb, for 3 h, lost the cell proliferation capacity (viability) and decreased intracellular GSH level. The Pb-induced loss of cell viability was compared among yeast cells deficient in GSH1 (∆gsh1) or GSH2 (∆gsh2) genes and wild-type (WT) cells. When exposed to Pb,...
Avaliação do papel da glutationa e do vacúolo como mecanismos de defesa contra ...
Perez, Rita R.A presença de metais pesados no meio ambiente deve-se, principalmente, a atividades antropogénicas. Ao contrário do Cu e do Zn, que em baixas concentrações são essenciais para o normal funcionamento celular, não se conhece para o chumbo nenhuma função biológica. O chumbo apresenta efeitos tóxicos, é considerado possível agente carcinogéneo, sendo classificado como poluente prioritário pela Agência de Proteção A...
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