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Common genetic polymorphisms in the ABCB1 gene are associated with risk of majo...
Santos, Marlene; Carvalho, Serafim; Lima, Luís; Nogueira, Augusto; Assis, Joana; Mota-Pereira, Jorge; Pimentel, Paulo; Maia, Dulce; Correia, DianaMajor depressive disorder (MDD) is a highly prevalent disorder, which has been associated with an abnormal response of the hypothalamus–pituitary–adrenal (HPA) axis. Reports have argued that an abnormal HPA axis response can be due to an altered P-Glycoprotein (P-GP) function. This argument suggests that genetic polymorphisms in ABCB1 may have an effect on the HPA axis activity; however, it is still not clear i...
The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy res...
Silva, Inês Hilário; Silva, Cristina Nogueira; Figueiredo, Tiago; Lombo, Liliana; Faustino, Ilda; Catarino, Raquel; Nogueira, Augusto; Pereira, DeolindaUncorrected proof ; Aims: Cervical cancer is the third most frequent cancer in women worldwide, mostly treated with cisplatin-based chemoradiotherapy. Since it is known that folate metabolism might interfere with cisplatin effectiveness, we intended to study the influence of the Gamma Glutamyl Hydrolase -401C > T polymorphism in treatment response in cervical cancer. Methods: We retrospectively reviewed the ...
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