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Cellular and molecular mechanisms controlling the migration of telencephalic in...

The homeodomain transcription factor Nkx2-1 plays fundamental roles in the development of the ventral subpallium. As for the majority of NK-2 class of transcription factors, Nkx2-1 function mainly in controlling cell-fate decisions in progenitor cells, such as interpreting Sonic Hedgehog (Shh) graded signalling in early patterning events and conferring subtype-specific properties to medial ganglionic eminence (...