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The association of p16INK4A and fragile histidine triad gene expression and cer...
Longatto Filho, Adhemar; Etlinger, Daniela; Pereira, Sónia Maria Miranda; Kanamura, Cristina Takami; Loreto, Celso di; Santos, Gilda da CunhaObjective. This cross-sectional study was intended to assess the association between immunohistochemical analysis of p16INK4A and fragile histidine triad (FHIT) and the presence of precancerous cervical lesions. Materials and Methods. Women seen at Pe´ rola Byington Hospital, São Paulo, Brazil, with histologically confirmed cervicitis (n = 31), cervical intraepithelial neoplasia (CIN) 1 (n = 30), CIN 2,3 (n = 3...
Prevalência de papilomavirus humano (HPV) anal, genital e oral, em ambulatório ...
Magi,João Carlos; Brito,Elisa Maria da Silva; Grecco,Elisabete Taeko Onaga; Pereira,Sonia Maria Miranda; Formiga,Galdino José SitonioO Papilomavirus Humano (HPV) anal tem alta prevalência e incidência na população. O objetivo deste trabalho é verificar a prevalência de HPV anal, bucal e genital em ambulatório público de Coloproctologia, com base no exame de captura hibrida. Foram estudados 64 pacientes atendidos no ambulatório geral de Coloproctologia do Hospital Heliópolis, no período de 22/11/2005 a 20/12/2005, onde foram levantados, de fo...
Screening for cervical Cancer in high-risk populations : DNA pap test or hybrid...
Pereira, Sónia Maria Miranda; Castelo, A.; Makabe, Sérgio; Utagawa, Maria Lúcia; Loreto, Celso di; Maeda, Marina Yoshiê Sakamoto; Marques, José A.This study was designed to evaluate whether Hybrid Capture II (HC2) test alone refer women to colposcopy as appropriately as DNA Papanicolaou (Pap) test, in the context of a high-risk group of women using the recently validated DNACitoliq LBC system. Women with suspected cervical disease were included in this crosssectional study at a tertiary center in São Paulo, Brazil, for further workup. All women had cervi...
O impacto do diagnóstico citológico de atipiasi indeterminadas no sistema públi...
Pereira, Sónia Maria Miranda; Yamamoto, Luzia S. U.; Loreto, Celso di; Silva, Luciana A.; Makabe, Sérgio; Marques, João A.As alterações citológicas de significado indeterminado representam uma importante limitação diagnóstica nos programas de escrutíneo de lesões cérvico-vaginais. A introdução de métodos biomoleculares, como o sistema de captura híbrida para detecção de HPV de alto risco contribui para a otimização da conduta clínica dessas pacientes, indicando colposcopia com precisão. Objetivo: avaliar o significado de lesões de...
Immunocytochemical expression of p16 INK4A and Ki-67 in cytologically negative ...
Longatto Filho, Adhemar; Utagawa, Maria Lúcia; Shirata, Neuza Kasumi; Pereira, Sónia Maria Miranda; Namiyama, Gislene; Kanamura, Cristina TakamiThis study was designed to analyze the cross-sectional comparison of the p16 INK4A and Ki-67 immunocytochemical expression in negative and equivocal (atyp-ical squamous cells of undetermined significance (ASC-US)) liquid-based cytology (LBC) samples testing positive for high-risk human papillomavirus (HPV) types with HC2 assay or polymerase-chain reaction (PCR). A series of 199 consecutive LBC speci-mens derive...
DCS liquid-based system is more effective than conventional smears to diagnosis...
Longatto Filho, Adhemar; Pereira, Sónia Maria Miranda; Loreto, Celso di; Utagawa, Maria Lúcia; Makabe, Sérgio; Maeda, Marina Yoshiê SakamotoObjective. To compare the performances of Papanicolaou test (PapTest) and of a new liquid-based cytology method, DNA-CitoliqR System (DCS), in a high-risk population, with histology confirmation. Methods. Paired specimens of exfoliated cervical cells were collected under split-sample protocol. All patients were submitted to colposcopy and a biopsy taken when any atypical transformation zone was seen. Sensitivit...
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