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Circulating cell-free DNA levels in Portuguese patients with psoriasis vulgaris...

associated with inflammation. OBJECTIVES: We aimed to understand the relation of CFD levels with psoriasis severity, defined by the Psoriasis Area and Severity Index (PASI), with inflammation and with psoriasis therapy. METHODS: Forty-six patients with psoriasis vulgaris were evaluated before (T0) and after 12 weeks (T12) of treatment with narrowband ultraviolet light B (NB-UVB; n = 17), psoralen plus UVA (PUVA...

Padrão terapêutico numa população de diabéticos tipo 2: relação com o te...

Introdução A diabetes mellitus tipo 2 (DM2) exige alterações terapêuticas constantes e cuidados de saúde diferenciados ao longo da sua evolução. Objetivo caracterizar uma população de DM2 internados quanto ao tempo de evolução, seguimento médico, tratamento, HbA1c, motivo e tempo de internamento. Materiais e métodos Estudo transversal baseado nos processos clínicos dos doentes com DM2 internados ...

Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of ...

OBJECTIVES: Bilirubin has potential antioxidant and anti-inflammatory properties. The UGT1A1*28 polymorphism (TA repeats in the promoter region) is a major determinant of bilirubin levels and recent evidence suggests that raised adiposity may also be a contributing factor. We aimed to study the interaction between UGT1A1 polymorphism, hematological and anthropometric variables with total bilirubin levels in you...

Renal amyloidosis: classification of 102 consecutive cases

Amyloidoses are a group of heterogeneous diseases classified according to the nature of their causative amyloid proteins. Commonly, paraffin-embedded tissue is used for the typing of amyloid by immunohistochemistry. DNA analysis should always be considered if hereditary amyloidosis is suspected. Since the kidneys are one of the organs that are most commonly involved in amyloid deposition in systemic amyloidoses...

Duration of Antibiotic Therapy in Bacterial Meningitis

The duration of antibiotic therapy in bacterial meningitis is a controversial issue. Antibiotic regimens have changed over time along with the criteria used to determine the ideal antibiotic therapy duration. The authors aim to make an historical overview on this matter and simultaneously add the evidence of recent studies, pointing out some issues in results interpretation, namely, their design and the associa...

ABO-Incompatible Liver Transplantation in Acute Liver Failure: A Single Portugu...

INTRODUCTION: ABO-incompatible liver transplantation (ABOi LT) is considered to be a rescue option in emergency transplantation. Herein, we have reported our experience with ABOi LT including long-term survival and major complications in these situations. PATIENT AND METHODS: ABOi LT was performed in cases of severe hepatic failure with imminent death. The standard immunosuppression consisted of basiliximab, c...

Melhoramento do sobreiro para uma regeneração artificial sustentável

O sobreiro (Quercus suber) é uma espécie singular devido à sua importância no funcionamento do ecossistema mediterrânico e na produção de cortiça. No entanto, apesar da sua importância ecológica e sócio-económica, pouco se compreende ainda dos seus processos de adaptabilidade às diferentes condições ambientais. Em algumas áreas do mediterrâneo ocidental, as florestas de sobreiro encontram-se em declínio e a man...

Characterizations of global reachability of 2D structured systems

Chemopreventive Efficacy of Atorvastatin against Nitrosamine-Induced Rat Bladde...

To investigate the anti-carcinogenic effects of Atorvastatin (Atorva) on a rat bladder carcinogenesis model with N-butyl-N-(4-hydroxibutil)nitrosamine (BBN), four male Wistar rat groups were studied: (1) Control: vehicle; (2) Atorva: 3 mg/kg bw/day; (3) Carcinogen: BBN (0.05%); (4) Preventive Atorva: 3 mg/kg bw/day Atorva + BBN. A two phase protocol was used, in which the drug and the carcinogen were given betw...

Infeção do trato urinário - agentes etiológicos e padrão de resistência local

RESUMO Introdução: A infeção urinária é uma patologia comum em idade pediátrica. A antibioterapia deve ser iniciada empiricamente antes do isolamento do agente causal e os fármacos utilizados devem ter em conta os microrganismos e o padrão de resistência local. Objetivos: Identificação dos agentes etiológicos de infeção urinária e os seus padrões de resistência antibiótica no nosso hospital. Material e Métodos:...