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Impact of EGFR genetic variants on glioma risk and patient outcome
Costa, Bruno Marques; Pereira, Marta Viana; Fernandes, Ricardo; Costa, S.; Linhares, Paulo; Vaz, Rui; Pinheiro, Céline; Lima, Jorge; Soares, PaulaB.M. Costa and M. Viana-Pereira contributed equally to this work; The authors thank the Immunochemotherapy Department of Hospital S. Marcos, and Clinica Laboratorial Dr. Edgar Botelho Moniz, S. Tirso, Portugal, for their helpful assistance in the management of controls ; BACKGROUND: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. ...
Microsatellite instability in pediatric high grade glioma is associated with ge...
Pereira, Marta Viana; Lee, Alicia; Popov, Sergey; Bax, Dorine A.; Al-Sarraj, Safa; Bridges, Leslie R.; Stávale, João N.; Jones, Chris; Reis, R. M.The authors would like to thank Dr. Steve Jackson's Laboratory at the University of Cambridge for the MRE11 antibody and Dr. Sandra Costa from ICVS, University of Minho, for the disease-free controls DNA ; High grade gliomas (HGG) are one of the leading causes of cancer-related deaths in children, and there is increasing evidence that pediatric HGG may harbor distinct molecular characteristics compared to adul...
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