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Study of the safety, immunogenicity and efficacy of attenuated and killed Leish...
Amaral,VF; Teva,A; Oliveira-Neto,MP; Silva,AJ; Pereira,MS; Cupolillo,E; Porrozzi,R; Coutinho,SG; Pirmez,C; Beverley,SM; Grimaldi Jr,GWe have compared the efficacy of two Leishmania (Leishmania) major vaccines, one genetically attenuated (DHFR-TS deficient organisms), the other inactivated [autoclaved promastigotes (ALM) with bacillus Calmete-Guérin (BCG)], in protecting rhesus macaques (Macaca mulatta) against infection with virulent L. (L.) major. Positive antigen-specific recall proliferative response was observed in vaccinees (79% in atte...
Leishmania (Leishmania) major-infected rhesus macaques (Macaca mulatta) develop...
Amaral,VF; Teva,A; Porrozzi,R; Silva,AJ; Pereira,MS; Oliveira-Neto,MP; Grimaldi Jr,GSeven rhesus macaques were infected intradermally with 10(7) promastigotes of Leishmania (Leishmania) major. All monkeys developed a localized, ulcerative, self-healing nodular skin lesion at the site of inoculation of the parasite. Non-specific chronic inflammation and/or tuberculoid-type granulomatous reaction were the main histopathological manifestations of the disease. Serum Leishmania-specific antibodies ...
Derrame Pericárdico Recidivante. Um Caso de Angiosarcoma Cardíaco
Marcão, I; Fonseca, P; Pereira, MS; Ramos, A; Fontes, L; Amorim, H; Marques, C; Borges, LA case of angiosarcoma of the right atrium in a 59-year-old woman is reported, presenting as a recurrent hematic pericardial effusion. The usefulness of echocardiography in making the diagnosis is emphasized. The tumor was already disseminated at the time of the diagnosis. The patient was on palliative therapy, dying a few months later. The histological examination was done at autopsy. This case highlights the ...
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