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Differential glutamate-dependent and glutamate-independent adenosine A1 recepto...
Borycz, Janusz; Pereira, M. Fátima; Melani, Alessia; Rodrigues, Ricardo J.; Köfalvi, Attila; Panlilio, Leigh; Pedata, Felicita; Goldberg, Steven R.Adenosine and dopamine are two important modulators of glutamatergic neurotransmission in the striatum. However, conflicting reports exist about the role of adenosine and adenosine receptors in the modulation of striatal dopamine release. It has been previously suggested that adenosine A1 receptors localized in glutamatergic nerve terminals indirectly modulate dopamine release, by their ability to modulate glut...
Ecto-AMP Deaminase Blunts the ATP-Derived Adenosine A2A Receptor Facilitation o...
Magalhães-Cardoso, M. Teresa; Pereira, M. Fátima; Oliveira, Laura; Ribeiro, J. A.; Cunha, Rodrigo A.; Correia-de-Sá, PauloAt synapses, ATP is released and metabolised through ecto-nucleotidases forming adenosine, which modulates neurotransmitter release through inhibitory A1 or facilitatory A2A receptors, according to the amounts of extracellular adenosine. Neuromuscular junctions possess an ecto-AMP deaminase that can dissociate extracellular ATP catabolism from adenosine formation. In this study we have investigated the pattern ...
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