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Ln[DO3A-N-α-(pyrenebutanamido)propionate] complexes: optimized relaxivity and N...
Ferreira, M. F.; Pereira, G.; Martins, A. F.; Martins, C. I. O.; Prata, M. I. M.; Petoud, S.; Toth, E.; Ferreira, P. M. T.; Martins, J. A.We have proposed recently that the DO3A-N-α-(amino)propionate chelator and its amide conjugates are leads to targeted, high relaxivity, safe contrast agents for magnetic resonance imaging. In this work we illustrate further the expeditious nature and robustness of the synthetic methodologies developed by preparing the DO3A-N-(α-pyrenebutanamido)propionate chelator. Its Gd3+ chelate retains the optimized water e...
Grande queimado numa Unidade de Cuidados Intensivos Pediátricos – experiência d...
Francisco, T.; Nóbrega, S.; Valente, R.; Santos, M.; Pereira, G.; Estrada, J.; Serafim, Z.; Ventura, L.Introdução: A abordagem inicial do grande queimado até à sua estabilização hemodinâmica e hidroeletrolítica é fundamental para diminuir a morbimortalidade. Material e Métodos: Estudo retrospetivo, descritivo e analítico, de todos os internamentos por queimadura numa Unidade de Cuidados Intensivos Pediátricos durante o período de 20 anos (Abril/1991 a Dezembro/2010). Avaliaram-se parâmetros nosodemográficos, age...
The management of ingested foreign bodies in an Ear Nose and Throat emergency u...
Marçal, N; Soares, JB; Pereira, G; Guimarães, J; Godinho, TAIMS: To determine how often ingested foreign bodies are found and what parameters may predict their retrieval. METHODS: During 1 year, we prospectively studied all patients referred to our Ear Nose and Throat Emergency Unit because of foreign body ingestion. RESULTS: During the study, 204 (median age-42 years [10 months-84 years]) patients were admitted because of ingested foreign body. The most common was fis...
The management of ingested foreign bodies in an Ear Nose and Throat emergency u...
Marçal, N; Soares, JB; Pereira, G; Guimarães, J; Godinho, TAIMS: To determine how often ingested foreign bodies are found and what parameters may predict their retrieval. METHODS: During 1 year, we prospectively studied all patients referred to our Ear Nose and Throat Emergency Unit because of foreign body ingestion. RESULTS: During the study, 204 (median age-42 years [10 months-84 years]) patients were admitted because of ingested foreign body. The most common was fis...
Statistical tool combined with image analysis to characterize hydrodynamics and...
Ferreira, A. M. A.; Pereira, G.; Teixeira, J. A.; Rocha, F. A.Image analysis technique has been proved to be very effective in the quantification of particles size and morphology distributions in different work areas. In the present work this technique was combined with the discriminant factorial analysis (DFA) in order to allow the automatic identification of single bubbles (isolated bubbles without influence of surrounded bubbles) in multiphase systems. With the previou...
Positron emission tomography in the detection of occult primary head and neck c...
Pereira, G; Silva, JC; Monteiro, EBACKGROUND: The management of cervical lymph node metastases from an unknown primary tumor remains a controversial subject. Recently, Positron Emission Tomography (PET) has proved useful in the detection of these tumors, even after an unsuccessful conventional diagnostic workup. This study was performed to assess the role of PET in the detection of occult primary head and neck carcinomas. METHODS: A retrospecti...
Positron emission tomography in the detection of occult primary head and neck c...
Pereira, G; Silva, JC; Monteiro, EBACKGROUND: The management of cervical lymph node metastases from an unknown primary tumor remains a controversial subject. Recently, Positron Emission Tomography (PET) has proved useful in the detection of these tumors, even after an unsuccessful conventional diagnostic workup. This study was performed to assess the role of PET in the detection of occult primary head and neck carcinomas. METHODS: A retrospecti...
Overexpression of kermit/dGIPC is associated with lethality in Drosophila melan...
Pereira,G.B.; Valente,V.; de Queiroz,M.S.; Vianna,M.C.B.; Paçó-Larson,M.L.Insertional mutagenesis is an important tool for functional genomics in Drosophila melanogaster. The insertion site in the KG00562 mutant fly line has been mapped to the CG8709 (herein named DmLpin) locus and to the 3’ of kermit (also called dGIPC). This mutant line presents a high lethality rate resulting from a gain of function. To obtain some insight into the biological role of the mutated locus, we ha...
Survival and echocardiographic evaluation of dogs with idiopathic dilated cardi...
Soares,E.C.; Pereira,G.G.; Petrus,L.C.; Leomil Neto,M.; Yamaki,F.L.; Larsson,M.H.M.A.Sixty dogs with idiopathic dilated cardiomyopathy were randomly treated with traditional therapy - digitalis, diuretics, angiotensin-converting inhibitors - (group A) or treated with these drugs plus carvedilol (group B). Echocardiographic variables were measured before and after 3, 13, 26, and 52 weeks of treatment or until death. Comparisons between groups and time were performed. No significant differences b...
Expression and purification of the immunogenically active fragment B of the Par...
Nascimento,D.V.; Lemes,E.M.B.; Queiroz,J.L.S.; Silva Jr.,J.G.; Nascimento,H.J.; Silva,E.D.; Hirata Jr.,R.; Dias,A.A.S.O.; Santos,C.S.; Pereira,G.M.B.The construction of a hexahistidine-tagged version of the B fragment of diphtheria toxin (DTB) represents an important step in the study of the biological properties of DTB because it will permit the production of pure recombinant DTB (rDTB) in less time and with higher yields than currently available. In the present study, the genomic DNA of the Corynebacterium diphtheriae Park Williams 8 (PW8) vaccine strain ...
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