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How far ‘AUG-proximity effect’ goes?
Pereira, Francisco J.C.; Teixeira, Alexandre; Kong, Jian; Silva, Ana Luísa; Liebhaber, Stephen A.; Romão, LuísaNonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and selectively degrades mRNAs carrying premature termination codons (PTCs). We have previously shown that mRNAs carrying a PTC located in close proximity to the translation initiation AUG codon escape NMD. This was called the “AUG-proximity effect”. The present work illustrates that the extension of the AUG-proximity effect, i.e. to w...
Data: 2012
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Origem: Repositório Científico do Instituto Nacional de Saúde
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