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EGFR amplification and lack of activating mutations in metaplastic breast carci...
Reis Filho, Jorge S.; Pinheiro, Céline; Lambros, M. B. K.; Milanezi, Fernanda; Carvalho, Silvia; Savage, K.; Simpson, Pete T.; Jones, C.; Swift, S.Metaplastic breast carcinomas are reported to harbour epidermal growth factor receptor (EGFR) overexpression in up to 80% of the cases, but EGFR gene amplification is the underlying genetic mechanism in around one-third of these. In this study, EGFR gene amplification as defined by chromogenic in situ hybridization and protein overexpression was examined in a cohort of 47 metaplastic breast carcinomas. Furtherm...
Metaplastic breast carcinomas are basal-like tumours
Reis Filho, Jorge S.; Milanezi, Fernanda; Steele, D.; Savage, K.; Simpson, Pete T.; Nesland, J. M.; Pereira, Emílio M.; Lakhani, Sunil R.Recently, an immunohistochemical panel comprising antibodies against HER2, estrogen receptor (ER), epidermal growth factor receptor (EGFR) and cytokeratin (CK) 5 ⁄ 6 was reported to identify basal-like breast carcinomas, as defined by cDNA microarrays. Our aim was to analyse a series of metaplastic breast carcinomas (MBCs) using this panel plus two other basal markers (CK14 and p63) and progesterone receptor (...
Novel and classic myoepithelial/stem cell markers in metaplastic carcinomas of ...
Reis Filho, Jorge S.; Milanezi, Fernanda; Paredes, Joana; Silva, Paula; Pereira, Emílio M.; Maeda, Sueli A.; Carvalho, Leda V. de; Schmitt, Fernando C.Metaplastic carcinomas of the breast (MCBs) are unusual neoplasms characterized by an admixture of glandular epithelial components, which frequently exhibit features of squamous differentiation, and mesenchymal malignant components. Regardless of the presence of myoepithelial features in MCB, no consensus concerning their putative histogenesis has yet been achieved. Recently, novel putative myoepithelial marker...
Oligodendroglioma cístico e positividade das reações para cisticercose relato d...
Agapejev,Svetlana; Alves,Armando; Zanini,Marco A.; Ueda,Anete K.; Pereira,Emílio M.São poucos os estudos sobre gliomas «low-grade». Os oligodendrogliomas representam de 1,3 a 10% dos tumores intracerebrais. A neurocisticercose é uma das mais graves parasitoses do SNC, com evidente polimorfismo clínico e laboratorial. O objetivo deste estudo é relatar o caso de um doente com cefaléia, perda progressiva da visão, alteração do comportamento e, provas imunológicas positivas para cisticercose no l...
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