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The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy res...
Silva, Inês Hilário; Silva, Cristina Nogueira; Figueiredo, Tiago; Lombo, Liliana; Faustino, Ilda; Catarino, Raquel; Nogueira, Augusto; Pereira, DeolindaUncorrected proof ; Aims: Cervical cancer is the third most frequent cancer in women worldwide, mostly treated with cisplatin-based chemoradiotherapy. Since it is known that folate metabolism might interfere with cisplatin effectiveness, we intended to study the influence of the Gamma Glutamyl Hydrolase -401C > T polymorphism in treatment response in cervical cancer. Methods: We retrospectively reviewed the ...
The predictive and monitoring value of serum HER2/NEU in breast cancer under tr...
Couto, Maria do Rosário; Pinto, Daniela; Oliveira, Júlio; Monteiro, Alice; Pereira, Deolinda; Medeiros, Rui; Rodrigues, HelenaIn breast cancer, the Human Epidermal growth factor Receptor 2 (HER2) is associated with worst prognosis in all stages of the disease, and it is specifically targeted by a monoclonal antibody (trastuzumab). Nevertheless, the different response rates observed have increased the search for better predictive markers. Elevated levels of the extracellular domain of HER2/neu in the serum have been associated with the...
Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ...
Costa, Sandra Maria Araújo da; Pinto, Daniela; Pereira, Deolinda; Vasconcelos, André; Lopes, Carlos Afonso; Osório, Teresa; Lopes, Carlos; Medeiros, RuiThe purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case–control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (ORZ2.46 95% CI 1.20–5.06; PZ...
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