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Pathological role of interleukin 17 in mice subjected to repeated BCG vaccinati...

Castro, Ant??nio G.; Fraga, Alexandra G.; Fountain, Jeffrey J.; Rangel-Moreno, Javier; Torrado, Eg??dio; Saraiva, Margarida

Infection usually leads to the development of acquired immune responses associated with clearance or control of the infecting organism. However, if not adequately regulated, immune-mediated pathology can result. Tuberculosis is a worldwide threat, and development of an effective vaccine requires that the protective immune response to Mycobacterium tuberculosis (Mtb) be dissected from the pathological immune res...


Mycobacterium ulcerans Triggers T-cell immunity followed by local and regional ...

Fraga, Alexandra G.; Cruz, Andrea; Martins, Teresa G.; Torrado, Egídio; Saraiva, Margarida; Pereira, Daniela Maria Ramos; Meyers, Wayne M.

Buruli ulcer (BU) is a neglected infectious disease caused by Mycobacterium ulcerans, characterized by necrotic cutaneous lesions induced by the exotoxin mycolactone. Despite evidence of Th1-mediated protective immunity, M. ulcerans infection has been associated with systemic immunosuppression. We show that early during mouse infection with either mycolactone-positive or negative strains, pathogen-specific IFN-...


TLR2 deficiency by compromising p19 (IL-23) expression limits T helper 17 cell ...

Coelho, Maria Teixeira; Cruz, Andrea; Carmona, J. A.; Sousa, Carole Lara Veiga de; Pereira, Daniela Maria Ramos; Saraiva, Ana Laura; Veldhoen, Marc

The authors are grateful to Drs. Manuel Teixeira da Silva, Fernando Rodrigues, Margarida Correia-Neves and Paul S. Redford for critically reading this manuscript and thank the personnel at the ICVS animal house facility for excellent animal husbandry. ; CD4+ Th1 cells producing IFN-γ are of extreme importance in controlling infections by Mycobacterium tuberculosis both in mice and in men. In addition to IFN-γ-...


Modulation of the immune response to mycobacteria : implications on protection ...

Pereira, Daniela Maria Ramos

Dissertação de mestrado em Genética Molecular ; Effective control of Mycobacterium tuberculosis infection requires the induction of inflammatory T helper (Th) 1 responses and avoidance of tissue damage. However, little is known about the mechanisms that rule the fine balance between protection and pathology in this infection. The anti-inflammatory cytokine IL-10 is important for the regulation of the immune re...


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