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Activation of adenosine A2A receptors induces TrkB translocation and increases ...
Assaife-Lopes, Natália; Sousa, Vasco C.; Pereira, Daniela B.; Ribeiro, Joaquim A.; Chao, Moses V.; Sebastião, Ana M.Copyright © 2010 the authors ; Brain-derived neurotrophic factor (BDNF) signaling is critical for neuronal development and transmission. Recruitment of TrkB receptors to lipid rafts has been hown to be necessary for the activation of specific signaling pathways and modulation of neurotransmitter release by BDNF. Since TrkB receptors are known to be modulated by adenosine A2A receptor activation, we hypothesize...
Surto de pitiose cutânea em bovinos
Gabriel,Adriane L.; Kommers,Glaucia D.; Trost,Maria E.; Barros,Claudio S.L.; Pereira,Daniela B.; Schwendler,Stela E.; Santurio,Janio M.Setenta e seis bovinos, sem raça definida, jovens, de ambos os sexos, apresentaram lesões cutâneas multifocais nodulares, ulceradas e crostosas nas faces medial e lateral dos membros anteriores e posteriores, região ventral do pescoço, esterno e cauda. A doença ocorreu no verão e as lesões foram observadas nas regiões do corpo que ficavam grande tempo em contato com a água em canais de irrigação. Histologicamen...
BDNF regulates the expression and traffic of NMDA receptors in cultured hippoca...
Caldeira, Margarida V.; Melo, Carlos V.; Pereira, Daniela B.; Carvalho, Ricardo F.; Carvalho, Ana Luísa; Duarte, Carlos B.The neurotrophin BDNF regulates the activity-dependent modifications of synaptic strength in the CNS. Physiological and biochemical evidences implicate the NMDA glutamate receptor as one of the targets for BDNF modulation. In the present study, we investigated the effect of BDNF on the expression and plasma membrane abundance of NMDA receptor subunits in cultured hippocampal neurons. Acute stimulation of hippoc...
Brain-derived neurotrophic factor regulates the expression and synaptic deliver...
Caldeira, Margarida V.; Melo, Carlos V.; Pereira, Daniela B.; Carvalho, Ricardo; Correia, Susana S.; Backos, Donald S.; Carvalho, Ana LuísaBrain-derived neurotrophic factor (BDNF) plays an important role in synaptic plasticity in the hippocampus, but the mechanisms involved are not fully understood. The neurotrophin couples synaptic activation to changes in gene expression underlying long term potentiation and short term plasticity. Here we show that BDNF acutely up-regulates GluR1, GluR2, and GluR3 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propi...
Trkb receptors modulation of glutamate release is limited to a subset of nerve ...
Pereira, Daniela B.; Rebola, Nelson; Rodrigues, Ricardo J.; Cunha, Rodrigo A.; Carvalho, Arsélio P.; Duarte, Carlos B.Brain-derived neurotrophic factor (BDNF) modulates glutamatergic excitatory transmission in hippocampal primary cultures by acting at a presynaptic locus. Although it has been suggested that BDNF also modulates adult hippocampus glutamatergic transmission, this remains a matter of controversy. To clarify a putative role for this neurotrophin in the modulation of glutamate release we applied exogenous BDNF to is...
Genistein inhibits Ca2+ influx and glutamate release from hippocampal synaptoso...
Pereira, Daniela B.; Carvalho, Arsélio P.; Duarte, Carlos B.The role of protein tyrosine kinases on glutamate release was investigated by determining the effect of broad range inhibitors of tyrosine kinases on the release of glutamate from rat hippocampal synaptosomes. We found that lavendustin A and herbimycin A did not inhibit glutamate release stimulated by 15 mM KCl, but genistein, also a broad range inhibitor of tyrosine kinases did inhibit the intracellular Ca2+ c...
Analysis of the presynaptic signaling mechanisms underlying the inhibition of L...
Pereira, Daniela B.; Duarte, Carlos B.No abstract. ; http://dx.doi.org/10.1002/hipo.10148
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